A Trp-BODIPY cyclic peptide for fluorescence labelling of apoptotic bodies

Ramon Subiros-funosas, Lorena Mendive-tapia, Jesus Sot, John D. Pound, Nicole Barth, Yaiza Varela, Felix Goñi, Margaret Paterson, Christopher D. Gregory, Fernando Albericio, Ian Dransfield, Rodolfo Lavilla Grifols, Marc Vendrell

Research output: Contribution to journalArticlepeer-review

Abstract

The rational design and synthesis of a Trp-BODIPY cyclic peptide for the fluorescent labelling of apoptotic bodies is described. Affinity assays, confocal microscopy and flow cytometry analysis confirmed the binding of the peptide to negatively-charged
phospholipids associated with apoptosis, and its applicability for the detection and characterisation of subcellular structures released by apoptotic cells
Original languageEnglish
JournalChemical Communications
Early online date15 Dec 2016
DOIs
Publication statusE-pub ahead of print - 15 Dec 2016

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