A Trp-BODIPY cyclic peptide for fluorescence labelling of apoptotic bodies

Ramon Subiros-funosas; Lorena Mendive-tapia; Jesus Sot; John D. Pound; Nicole Barth; Yaiza Varela; Felix Goñi; Margaret Paterson; Christopher D. Gregory; Fernando Albericio; Ian Dransfield; Rodolfo Lavilla Grifols; Marc Vendrell

doi:10.1039/C6CC07879F

A Trp-BODIPY cyclic peptide for fluorescence labelling of apoptotic bodies

Ramon Subiros-funosas, Lorena Mendive-tapia, Jesus Sot, John D. Pound, Nicole Barth, Yaiza Varela, Felix Goñi, Margaret Paterson, Christopher D. Gregory, Fernando Albericio, Ian Dransfield, Rodolfo Lavilla Grifols, Marc Vendrell

Research output: Contribution to journal › Article › peer-review

Abstract

The rational design and synthesis of a Trp-BODIPY cyclic peptide for the fluorescent labelling of apoptotic bodies is described. Affinity assays, confocal microscopy and flow cytometry analysis confirmed the binding of the peptide to negatively-charged
phospholipids associated with apoptosis, and its applicability for the detection and characterisation of subcellular structures released by apoptotic cells

Original language	English
Journal	Chemical Communications
Early online date	15 Dec 2016
DOIs	https://doi.org/10.1039/C6CC07879F
Publication status	E-pub ahead of print - 15 Dec 2016

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http://pubs.rsc.org/en/Content/ArticleLanding/2016/CC/C6CC07879F

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ENDOIMAGE - Activatable Fluorescent Probes as Smart Diagnostic Tools for Microendoscopy Imaging
Vendrell Escobar, M.
EU other
1/08/13 → 31/07/17
Project: Research

Marc Vendrell Escobar
- marc.vendrelled.acuk
- mvendrelstaffmail.ed.acuk
- Deanery of Clinical Sciences - Personal Chair Translational Chemistry & Biomedical Imaging
- Centre for Inflammation Research
Person: Academic: Research Active

Cite this

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title = "A Trp-BODIPY cyclic peptide for fluorescence labelling of apoptotic bodies",

abstract = "The rational design and synthesis of a Trp-BODIPY cyclic peptide for the fluorescent labelling of apoptotic bodies is described. Affinity assays, confocal microscopy and flow cytometry analysis confirmed the binding of the peptide to negatively-chargedphospholipids associated with apoptosis, and its applicability for the detection and characterisation of subcellular structures released by apoptotic cells",

author = "Ramon Subiros-funosas and Lorena Mendive-tapia and Jesus Sot and Pound, {John D.} and Nicole Barth and Yaiza Varela and Felix Go{\~n}i and Margaret Paterson and Gregory, {Christopher D.} and Fernando Albericio and Ian Dransfield and {Lavilla Grifols}, Rodolfo and Marc Vendrell",

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language = "English",

journal = "Chemical Communications",

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T1 - A Trp-BODIPY cyclic peptide for fluorescence labelling of apoptotic bodies

AU - Subiros-funosas, Ramon

AU - Mendive-tapia, Lorena

AU - Sot, Jesus

AU - Pound, John D.

AU - Barth, Nicole

AU - Varela, Yaiza

AU - Goñi, Felix

AU - Paterson, Margaret

AU - Gregory, Christopher D.

AU - Albericio, Fernando

AU - Dransfield, Ian

AU - Lavilla Grifols, Rodolfo

AU - Vendrell, Marc

PY - 2016/12/15

Y1 - 2016/12/15

N2 - The rational design and synthesis of a Trp-BODIPY cyclic peptide for the fluorescent labelling of apoptotic bodies is described. Affinity assays, confocal microscopy and flow cytometry analysis confirmed the binding of the peptide to negatively-chargedphospholipids associated with apoptosis, and its applicability for the detection and characterisation of subcellular structures released by apoptotic cells

AB - The rational design and synthesis of a Trp-BODIPY cyclic peptide for the fluorescent labelling of apoptotic bodies is described. Affinity assays, confocal microscopy and flow cytometry analysis confirmed the binding of the peptide to negatively-chargedphospholipids associated with apoptosis, and its applicability for the detection and characterisation of subcellular structures released by apoptotic cells

U2 - 10.1039/C6CC07879F

DO - 10.1039/C6CC07879F

M3 - Article

JO - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

ER -

A Trp-BODIPY cyclic peptide for fluorescence labelling of apoptotic bodies

Abstract

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