A variant in intron 11 of RXFP2 gene is associated with the polled phenotype in North Aegean sheep populations

Antonios Kominakis, Ariadne Hager, Eirini Tarsani, Ioannis Hadjigeorgiou

Research output: Contribution to conferencePosterpeer-review

Abstract

In the present GWAS, first, we detected additive and dominant genetic variants associated with the horned/polled phenotype in a sheep population (n=256) dispersed on three Greek islands (Lemnos, Lesvos and Agios Efstratios) and second we identified the most plausible functional candidate gene for the trait under study. Marker-based heritability was as high as 0.26 and 0.16 in the additive and dominant model, respectively. Marker-trait association analyses revealed one highly significant marker, i.e. OAR10_29511510.1 (C>T) (additive p-value=4.82e-24, dominant p-value=1.52e-30) on ovine chromosome 10 that explained 0.37 and 0.43 of the phenotypic variance of the trait in the additive and dominant genetic model, respectively. This marker is located in intron 11 of RXFP2 (relaxin/insulin-like family peptide receptor 2) gene that has previously been implicated to horn development and types in various sheep breeds. Current findings are indicative of dominant gene action for polledness and confirmed the strong candidacy of the RXFP2 gene in the genetic control of presence/absence of horns in sheep.
Original languageEnglish
Publication statusPublished - 1 Dec 2020
EventEAAP 2020: 71st Annual Meeting of the European Federation of Animal Science -
Duration: 1 Dec 20204 Dec 2020

Conference

ConferenceEAAP 2020: 71st Annual Meeting of the European Federation of Animal Science
Period1/12/204/12/20

Fingerprint

Dive into the research topics of 'A variant in intron 11 of RXFP2 gene is associated with the polled phenotype in North Aegean sheep populations'. Together they form a unique fingerprint.

Cite this