A vertically integrated CMOS micro-system for time-resolved fluorescence analysis

Bruce R. Rae, Keith R. Muir, David Renshaw, Robert K. Henderson, John Girkin, Zheng Gong, Jonathan McKendry, Erdan Gu, Martin D. Dawson

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We describe a two-chip micro-scale time-resolved fluorescence analyzer integrating excitation, detection and filtering. A new 8x8 array of drivers integrated in standard lowvoltage 0.35μm CMOS is bump-bonded to AlInGaN blue micropixellated light-emitting diodes (micro-LED). The array is capable of producing sample excitation pulses with a width of 777ps (FWHM) enabling short lifetime fluorophores to be excited. The fluorescence emission is detected by a second, vertically-opposed 16x4 array of single-photon avalanche diodes (SPADs) fabricated in 0.35μm high-voltage CMOS technology with in-pixel time-gated photon counting circuitry. This constitutes the smallest reported solid-state micro-system for fluorescence decay analysis, replacing lasers, photomultiplier tubes, bulk optics and discrete electronics. The system is demonstrated with measurements of fluorescent colloidal quantum dot and Rhodamine samples.

Original languageEnglish
Title of host publication2009 IEEE Biomedical Circuits and Systems Conference, BioCAS 2009
Pages85-88
Number of pages4
DOIs
Publication statusPublished - 2009
Event2009 IEEE Biomedical Circuits and Systems Conference, BioCAS 2009 - Beijing, China
Duration: 26 Nov 200928 Nov 2009

Publication series

Name2009 IEEE Biomedical Circuits and Systems Conference, BioCAS 2009

Conference

Conference2009 IEEE Biomedical Circuits and Systems Conference, BioCAS 2009
Country/TerritoryChina
CityBeijing
Period26/11/0928/11/09

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