Abnormal first trimester serum interleukin 18 levels are associated with a poor outcome in women with a history of recurrent miscarriage

Rhoda Wilson, Judith Moor, Carol Jenkins, Helen Miller, James J Walker, Marjorie A McLean, J Norman, I B McInnes

Research output: Contribution to journalArticlepeer-review

Abstract

PROBLEM: How the maternal immune system adapts to tolerate the fetus is not fully understood, but a successful pregnancy is associated with the production of Th2-type cytokines and miscarriage is associated with the production of Th1-type cytokines.

METHOD OF STUDY: Levels of interferon (IFN)-gamma, interleukin (IL)-4, IL-12 and IL-18 were measured in serum from 205 pregnant women of whom 115 pregnant women had a history of recurrent miscarriage.

RESULTS: Compared with healthy pregnant women those who miscarried had increased serum levels of the Th1-associated cytokines IFN-gamma, IL-12 and IL-18.

CONCLUSIONS: Increased levels of IL-18 appeared to be critical in early pregnancy and were able to discriminate between pregnancies that continued and those that end in miscarriage.

Original languageEnglish
Pages (from-to)156-9
Number of pages4
JournalAmerican Journal of Reproductive Immunology
Volume51
Issue number2
Publication statusPublished - Feb 2004

Keywords

  • Abortion, Habitual
  • Cytokines
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Humans
  • Interleukin-18
  • Pregnancy
  • Pregnancy Outcome
  • Pregnancy Trimester, First
  • Prognosis
  • Th1 Cells
  • Th2 Cells

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