Abnormal Tr1 differentiation in multiple sclerosis

Anne L Astier, David A Hafler

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS). In the recent years, accumulating evidence has supported an immunosuppressive role for regulatory T cells (Tregs). Most studies in the context of autoimmunity have focused on the defects of the CD4+CD25 high Tregs. However, we recently demonstrated an altered function of Tr1 Treg cells in MS, characterized by a lack of IL-10 secretion. Therefore, several major regulatory T cell defects are involved in human autoimmune disease. Hence, the induction of Tregs or the stimulation of Treg activity may be beneficial for the treatment of such diseases.
Original languageEnglish
Pages (from-to)70-8
Number of pages9
JournalJournal of Neuroimmunology
Issue number1-2
Publication statusPublished - 2007

Keywords / Materials (for Non-textual outputs)

  • Animals
  • Antigens, CD46
  • Cell Differentiation
  • Herpesvirus 6, Human
  • Humans
  • Interleukin-10
  • Lymphocyte Activation
  • Multiple Sclerosis
  • Protein Isoforms
  • T-Lymphocytes, Regulatory


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