Abscission checkpoint control: stuck in the middle with Aurora B

Mar Carmena*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

At the end of cell division, the cytoplasmic bridge joining the daughter cells is severed through a process that involves scission of the plasma membrane. The presence of chromatin bridges 'stuck' in the division plane is sensed by the chromosomal passenger complex (CPC) component Aurora B kinase, triggering a checkpoint that delays abscission until the chromatin bridges have been resolved. Recent work has started to shed some light on the molecular mechanism by which the CPC controls the timing of abscission.

Original languageEnglish
Article number120095
Number of pages4
JournalOpen Biology
Volume2
DOIs
Publication statusPublished - Jul 2012

Keywords

  • aurora B kinase
  • chromosomal passenger complex
  • endosomal sorting complex required for transport-III
  • cytokinesis
  • abscission
  • checkpoint
  • cell division
  • borealin
  • phosphorylation
  • tumorigenesis

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