Abscission checkpoint control: stuck in the middle with Aurora B

Mar Carmena

doi:10.1098/rsob.120095

Abscission checkpoint control: stuck in the middle with Aurora B

Mar Carmena^*

^*Corresponding author for this work

School of Biological Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

At the end of cell division, the cytoplasmic bridge joining the daughter cells is severed through a process that involves scission of the plasma membrane. The presence of chromatin bridges 'stuck' in the division plane is sensed by the chromosomal passenger complex (CPC) component Aurora B kinase, triggering a checkpoint that delays abscission until the chromatin bridges have been resolved. Recent work has started to shed some light on the molecular mechanism by which the CPC controls the timing of abscission.

Original language	English
Article number	120095
Number of pages	4
Journal	Open Biology
Volume	2
DOIs	https://doi.org/10.1098/rsob.120095
Publication status	Published - Jul 2012

Keywords

aurora B kinase
chromosomal passenger complex
endosomal sorting complex required for transport-III
cytokinesis
abscission
checkpoint
cell division
borealin
phosphorylation
tumorigenesis

Access to Document

10.1098/rsob.120095Licence: Creative Commons: Attribution (CC-BY)

CarmenaEtalOB2012AbscissionCheckpointControlStuckInTheMiddleFinal published version, 454 KBLicence: Creative Commons: Attribution (CC-BY)

Cite this

@article{a646415bf1da45638be11b088b915572,

title = "Abscission checkpoint control: stuck in the middle with Aurora B",

abstract = "At the end of cell division, the cytoplasmic bridge joining the daughter cells is severed through a process that involves scission of the plasma membrane. The presence of chromatin bridges 'stuck' in the division plane is sensed by the chromosomal passenger complex (CPC) component Aurora B kinase, triggering a checkpoint that delays abscission until the chromatin bridges have been resolved. Recent work has started to shed some light on the molecular mechanism by which the CPC controls the timing of abscission.",

keywords = "aurora B kinase, chromosomal passenger complex, endosomal sorting complex required for transport-III, cytokinesis, abscission, checkpoint, cell division, borealin, phosphorylation, tumorigenesis",

author = "Mar Carmena",

year = "2012",

month = jul,

doi = "10.1098/rsob.120095",

language = "English",

volume = "2",

journal = "Open Biology",

issn = "2046-2441",

publisher = "Royal Society of Chemistry",

}

TY - JOUR

T1 - Abscission checkpoint control: stuck in the middle with Aurora B

AU - Carmena, Mar

PY - 2012/7

Y1 - 2012/7

N2 - At the end of cell division, the cytoplasmic bridge joining the daughter cells is severed through a process that involves scission of the plasma membrane. The presence of chromatin bridges 'stuck' in the division plane is sensed by the chromosomal passenger complex (CPC) component Aurora B kinase, triggering a checkpoint that delays abscission until the chromatin bridges have been resolved. Recent work has started to shed some light on the molecular mechanism by which the CPC controls the timing of abscission.

AB - At the end of cell division, the cytoplasmic bridge joining the daughter cells is severed through a process that involves scission of the plasma membrane. The presence of chromatin bridges 'stuck' in the division plane is sensed by the chromosomal passenger complex (CPC) component Aurora B kinase, triggering a checkpoint that delays abscission until the chromatin bridges have been resolved. Recent work has started to shed some light on the molecular mechanism by which the CPC controls the timing of abscission.

KW - aurora B kinase

KW - chromosomal passenger complex

KW - endosomal sorting complex required for transport-III

KW - cytokinesis

KW - abscission

KW - checkpoint

KW - cell division

KW - borealin

KW - phosphorylation

KW - tumorigenesis

U2 - 10.1098/rsob.120095

DO - 10.1098/rsob.120095

M3 - Article

VL - 2

JO - Open Biology

JF - Open Biology

SN - 2046-2441

M1 - 120095

ER -

Abscission checkpoint control: stuck in the middle with Aurora B

Abstract

Keywords

Access to Document

Fingerprint

Cite this