Absence of a relationship between immunophenotypic and colony enumeration analysis of endothelial progenitor cells in clinical haematopoietic cell sources

Olga Tura, G Robin Barclay, Huw Roddie, John Davies, Marc L Turner

Research output: Contribution to journalArticlepeer-review

Abstract

The discovery of adult endothelial progenitor cells (EPC) offers potential for vascular regenerative therapies. The expression of CD34 and VEGFR2 by EPC indicates a close relationship with haematopoietic progenitor cells (HPC), and HPC-rich sources have been used to treat cardiac and limb ischaemias with apparent clinical benefit. However, the laboratory characterisation of the vasculogenic capability of potential or actual therapeutic cell autograft sources is uncertain since the description of EPC remains elusive. Various definitions of EPC based on phenotype and more recently on colony formation (CFU-EPC) have been proposed.
Original languageEnglish
Pages (from-to)37
JournalJournal of translational medicine
Volume5
DOIs
Publication statusPublished - 2007

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