Absence of hepatitis A virus transmission by high-purity solvent detergent treated coagulation factor concentrates in Scottish haemophiliacs

H G Watson, C A Ludlam, F McOmish, R Dennis, H Hart, P Simmonds

Research output: Contribution to journalArticlepeer-review

Abstract

Recent reports of hepatitis A virus (HAV) infection in haemophiliacs receiving high-purity solvent detergent (HP.SD) treated factor VIII concentrates have brought into question the efficacy of this virucidal method for inactivating HAV. To assess whether HAV may have been transmitted by HP.SD concentrates, we compared seroprevalence in haemophiliacs with different disease severity, sought evidence of seroconversion to HAV since introduction of HP.SD products, and directly examined concentrates for HAV RNA by PCR. Our data suggest that Scottish haemophiliacs are not being infected with HAV by HP.SD concentrates produced initially by CRTS Lille and presently by PFC Edinburgh and supplied by the Scottish National Blood Transfusion Service (SNBTS).
Original languageEnglish
Pages (from-to)214-6
Number of pages3
JournalBritish journal of haematology
Volume89
Issue number1
DOIs
Publication statusPublished - Jan 1995

Keywords

  • Adolescent
  • Adult
  • Base Sequence
  • Child
  • Drug Contamination
  • Factor VIII
  • Hemophilia A
  • Hepatitis A
  • Hepatitis A Virus, Human
  • Humans
  • Male
  • Molecular Sequence Data
  • Organophosphates
  • Polymerase Chain Reaction
  • Polysorbates
  • Retrospective Studies

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