Accelerating biomedical discoveries in brain health through transformative neuropathology of aging and neurodegeneration

Melissa E. Murray; Colin Smith; Vilas Menon; C. Dirk Keene; Ed Lein; Michael Hawrylycz; Adriano Aguzzi; Brett Benedetti; Katja Brose; Kelsey Caetano-Anolles; Maria Inmaculada Cobos Sillero; John F. Crary; Philip L. De Jager; Arline Faustin; Margaret E. Flanagan; Ozgun Gokce; Seth G.N. Grant; Lea T. Grinberg; David A. Gutman; Elizabeth M.C. Hillman; Zhi Huang; David J. Irwin; David T. Jones; Alifiya Kapasi; Celeste M. Karch; Walter T. Kukull; Tammaryn Lashley; Edward B. Lee; Thomas Lehner; Laura Parkkinen; Maria Pedersen; Dominique Pritchett; Matthew H. Rutledge; Julie A. Schneider; William W. Seeley; Claire E. Shepherd; Tara L. Spires-Jones; Judith A. Steen; Margaret Sutherland; Sanja Vickovic; Bin Zhang; David J. Stewart; Michael J. Keiser; Jacob W. Vogel; Brittany N. Dugger; Hemali Phatnani

doi:10.1016/j.neuron.2025.06.014

Accelerating biomedical discoveries in brain health through transformative neuropathology of aging and neurodegeneration

Melissa E. Murray^*, Colin Smith, Vilas Menon, C. Dirk Keene, Ed Lein, Michael Hawrylycz, Adriano Aguzzi, Brett Benedetti, Katja Brose, Kelsey Caetano-Anolles, Maria Inmaculada Cobos Sillero, John F. Crary, Philip L. De Jager, Arline Faustin, Margaret E. Flanagan, Ozgun Gokce, Seth G.N. Grant, Lea T. Grinberg, David A. Gutman, Elizabeth M.C. HillmanZhi Huang, David J. Irwin, David T. Jones, Alifiya Kapasi, Celeste M. Karch, Walter T. Kukull, Tammaryn Lashley, Edward B. Lee, Thomas Lehner, Laura Parkkinen, Maria Pedersen, Dominique Pritchett, Matthew H. Rutledge, Julie A. Schneider, William W. Seeley, Claire E. Shepherd, Tara L. Spires-Jones, Judith A. Steen, Margaret Sutherland, Sanja Vickovic, Bin Zhang, David J. Stewart, Michael J. Keiser, Jacob W. Vogel, Brittany N. Dugger, Hemali Phatnani^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Original language	English
Journal	Neuron
Early online date	18 Jul 2025
DOIs	https://doi.org/10.1016/j.neuron.2025.06.014
Publication status	E-pub ahead of print - 18 Jul 2025

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Murray, M. E., Smith, C., Menon, V., Keene, C. D., Lein, E., Hawrylycz, M., Aguzzi, A., Benedetti, B., Brose, K., Caetano-Anolles, K., Sillero, M. I. C., Crary, J. F., De Jager, P. L., Faustin, A., Flanagan, M. E., Gokce, O., Grant, S. G. N., Grinberg, L. T., Gutman, D. A., ... Phatnani, H. (2025). Accelerating biomedical discoveries in brain health through transformative neuropathology of aging and neurodegeneration. Neuron. Advance online publication. https://doi.org/10.1016/j.neuron.2025.06.014

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title = "Accelerating biomedical discoveries in brain health through transformative neuropathology of aging and neurodegeneration",

author = "Murray, \{Melissa E.\} and Colin Smith and Vilas Menon and Keene, \{C. Dirk\} and Ed Lein and Michael Hawrylycz and Adriano Aguzzi and Brett Benedetti and Katja Brose and Kelsey Caetano-Anolles and Sillero, \{Maria Inmaculada Cobos\} and Crary, \{John F.\} and \{De Jager\}, \{Philip L.\} and Arline Faustin and Flanagan, \{Margaret E.\} and Ozgun Gokce and Grant, \{Seth G.N.\} and Grinberg, \{Lea T.\} and Gutman, \{David A.\} and Hillman, \{Elizabeth M.C.\} and Zhi Huang and Irwin, \{David J.\} and Jones, \{David T.\} and Alifiya Kapasi and Karch, \{Celeste M.\} and Kukull, \{Walter T.\} and Tammaryn Lashley and Lee, \{Edward B.\} and Thomas Lehner and Laura Parkkinen and Maria Pedersen and Dominique Pritchett and Rutledge, \{Matthew H.\} and Schneider, \{Julie A.\} and Seeley, \{William W.\} and Shepherd, \{Claire E.\} and Spires-Jones, \{Tara L.\} and Steen, \{Judith A.\} and Margaret Sutherland and Sanja Vickovic and Bin Zhang and Stewart, \{David J.\} and Keiser, \{Michael J.\} and Vogel, \{Jacob W.\} and Dugger, \{Brittany N.\} and Hemali Phatnani",

year = "2025",

month = jul,

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doi = "10.1016/j.neuron.2025.06.014",

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Murray, ME, Smith, C, Menon, V, Keene, CD, Lein, E, Hawrylycz, M, Aguzzi, A, Benedetti, B, Brose, K, Caetano-Anolles, K, Sillero, MIC, Crary, JF, De Jager, PL, Faustin, A, Flanagan, ME, Gokce, O, Grant, SGN, Grinberg, LT, Gutman, DA, Hillman, EMC, Huang, Z, Irwin, DJ, Jones, DT, Kapasi, A, Karch, CM, Kukull, WT, Lashley, T, Lee, EB, Lehner, T, Parkkinen, L, Pedersen, M, Pritchett, D, Rutledge, MH, Schneider, JA, Seeley, WW, Shepherd, CE, Spires-Jones, TL, Steen, JA, Sutherland, M, Vickovic, S, Zhang, B, Stewart, DJ, Keiser, MJ, Vogel, JW, Dugger, BN & Phatnani, H 2025, 'Accelerating biomedical discoveries in brain health through transformative neuropathology of aging and neurodegeneration', Neuron. https://doi.org/10.1016/j.neuron.2025.06.014

TY - JOUR

T1 - Accelerating biomedical discoveries in brain health through transformative neuropathology of aging and neurodegeneration

AU - Murray, Melissa E.

AU - Smith, Colin

AU - Menon, Vilas

AU - Keene, C. Dirk

AU - Lein, Ed

AU - Hawrylycz, Michael

AU - Aguzzi, Adriano

AU - Benedetti, Brett

AU - Brose, Katja

AU - Caetano-Anolles, Kelsey

AU - Sillero, Maria Inmaculada Cobos

AU - Crary, John F.

AU - De Jager, Philip L.

AU - Faustin, Arline

AU - Flanagan, Margaret E.

AU - Gokce, Ozgun

AU - Grant, Seth G.N.

AU - Grinberg, Lea T.

AU - Gutman, David A.

AU - Hillman, Elizabeth M.C.

AU - Huang, Zhi

AU - Irwin, David J.

AU - Jones, David T.

AU - Kapasi, Alifiya

AU - Karch, Celeste M.

AU - Kukull, Walter T.

AU - Lashley, Tammaryn

AU - Lee, Edward B.

AU - Lehner, Thomas

AU - Parkkinen, Laura

AU - Pedersen, Maria

AU - Pritchett, Dominique

AU - Rutledge, Matthew H.

AU - Schneider, Julie A.

AU - Seeley, William W.

AU - Shepherd, Claire E.

AU - Spires-Jones, Tara L.

AU - Steen, Judith A.

AU - Sutherland, Margaret

AU - Vickovic, Sanja

AU - Zhang, Bin

AU - Stewart, David J.

AU - Keiser, Michael J.

AU - Vogel, Jacob W.

AU - Dugger, Brittany N.

AU - Phatnani, Hemali

PY - 2025/7/18

Y1 - 2025/7/18

U2 - 10.1016/j.neuron.2025.06.014

DO - 10.1016/j.neuron.2025.06.014

M3 - Article

SN - 0896-6273

JO - Neuron

JF - Neuron

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