Accumulation of p53 is associated with tumour progression in cutaneous lesions of renal allograft recipients

L A Stark, M J Arends, K M McLaren, E C Benton, H Shahidullah, J A Hunter, C C Bird

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Renal allograft recipients suffer from a markedly increased susceptibility to premalignant and malignant cutaneous lesions. Although various aetiological factors have been implicated, little is known of the associated genetic events. In this study we initially employed immunocytochemical techniques to investigate the prevalence and localisation of accumulated p53 in over 200 cutaneous biopsies (including 56 squamous cell carcinomas) from renal allograft recipients and immunocompetent controls. In renal allograft recipients accumulated p53 was present in 24% of uninvolved skin samples, 14% of viral warts, 41% of premalignant keratoses, 65% of intraepidermal carcinomas and 56% of squamous cell carcinomas [squamous cell carcinoma and intraepidermal carcinoma differed significantly from uninvolved skin (P 50% of cells, reducing to 1/6 (17%) where 10-50% of cells were positively stained and none where
Original languageEnglish
Pages (from-to)662-7
Number of pages6
JournalBritish Journal of Cancer
Volume70
Issue number4
Publication statusPublished - Oct 1994

Keywords / Materials (for Non-textual outputs)

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Carcinoma in Situ
  • Carcinoma, Squamous Cell
  • Child
  • DNA, Viral
  • Exons
  • Genes, p53
  • Humans
  • Immunohistochemistry
  • Kidney Transplantation
  • Middle Aged
  • Mutation
  • Papillomaviridae
  • Polymorphism, Single-Stranded Conformational
  • Postoperative Complications
  • Precancerous Conditions
  • Sensitivity and Specificity
  • Skin Neoplasms
  • Tumor Suppressor Protein p53

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