Acquired immune heterogeneity and its sources in human helminth infection

C. D. Bourke, R. M. Maizels, F. Mutapi

Research output: Contribution to journalLiterature reviewpeer-review

Abstract

Similarities in the immunobiology of different parasitic worm infections indicate that co-evolution of humans and helminths has shaped a common anti-helminth immune response. However, recent in vitro and immuno-epidemiological studies highlight fundamental differences and plasticity within host-helminth interactions. The 'trade-off' between immunity and immunopathology inherent in host immune responses occurs on a background of genetic polymorphism, variable exposure patterns and infection history. For the parasite, variation in life-cycle and antigen expression can influence the effector responses directed against them. This is particularly apparent when comparing gastrointestinal and tissue-dwelling helminths. Furthermore, insights into the impact of anti-helminthic treatment and co-infection on acquired immunity suggest that immune heterogeneity arises not from hosts and parasites in isolation, but also from the environment in which immune responses develop. Large-scale differences observed in the epidemiology of human helminthiases are a product of complex host-parasite-environment interactions which, given potential for exposure to parasite antigens in utero, can arise even before a parasite interacts with its human host. This review summarizes key differences identified in human acquired immune responses to nematode and trematode infections of public health importance and explores the factors contributing to these variations.

Original languageEnglish
Pages (from-to)139-159
Number of pages21
JournalParasitology
Volume138
Issue number2
DOIs
Publication statusPublished - Feb 2011

Keywords

  • heterogeneity
  • helminth
  • human
  • nematode
  • trematode
  • schistosome
  • immune response

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