Actin-Based Motility of Burkholderia thailandensis Requires a Central Acidic Domain of BimA That Recruits and Activates the Cellular Arp2/3 Complex

Chayada Sitthidet; Joanne M. Stevens; Terence R. Field; Abigail N. Layton; Sunee Korbsrisate; Mark P. Stevens

doi:10.1128/JB.00608-10

Actin-Based Motility of Burkholderia thailandensis Requires a Central Acidic Domain of BimA That Recruits and Activates the Cellular Arp2/3 Complex

Chayada Sitthidet, Joanne M. Stevens, Terence R. Field, Abigail N. Layton, Sunee Korbsrisate, Mark P. Stevens

Research output: Contribution to journal › Article › peer-review

Abstract

Burkholderia species use BimA for intracellular actin-based motility. Uniquely, Burkholderia thailandensis BimA harbors a central and acidic (CA) domain. The CA domain was required for actin-based motility, binding to the cellular Arp2/3 complex, and Arp2/3-dependent polymerization of actin monomers. Our data reveal distinct strategies for actin-based motility among Burkholderia species.

Original language	English
Pages (from-to)	5249-5252
Number of pages	4
Journal	Journal of Bacteriology
Volume	192
Issue number	19
DOIs	https://doi.org/10.1128/JB.00608-10
Publication status	Published - Oct 2010

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10.1128/JB.00608-10

Actin-Based Motility of Burkholderia thailandensis Requires a Central Acidic Domain of BimA That Recruits and Activates the Cellular Arp2 3 ComplexFinal published version, 1.7 MB

http://jb.asm.org/content/192/19/5249

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abstract = "Burkholderia species use BimA for intracellular actin-based motility. Uniquely, Burkholderia thailandensis BimA harbors a central and acidic (CA) domain. The CA domain was required for actin-based motility, binding to the cellular Arp2/3 complex, and Arp2/3-dependent polymerization of actin monomers. Our data reveal distinct strategies for actin-based motility among Burkholderia species.",

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AU - Field, Terence R.

AU - Layton, Abigail N.

AU - Korbsrisate, Sunee

AU - Stevens, Mark P.

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AB - Burkholderia species use BimA for intracellular actin-based motility. Uniquely, Burkholderia thailandensis BimA harbors a central and acidic (CA) domain. The CA domain was required for actin-based motility, binding to the cellular Arp2/3 complex, and Arp2/3-dependent polymerization of actin monomers. Our data reveal distinct strategies for actin-based motility among Burkholderia species.

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Actin-Based Motility of Burkholderia thailandensis Requires a Central Acidic Domain of BimA That Recruits and Activates the Cellular Arp2/3 Complex

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