Actin-Based Motility of Burkholderia thailandensis Requires a Central Acidic Domain of BimA That Recruits and Activates the Cellular Arp2/3 Complex

Chayada Sitthidet, Joanne M. Stevens, Terence R. Field, Abigail N. Layton, Sunee Korbsrisate, Mark P. Stevens

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Burkholderia species use BimA for intracellular actin-based motility. Uniquely, Burkholderia thailandensis BimA harbors a central and acidic (CA) domain. The CA domain was required for actin-based motility, binding to the cellular Arp2/3 complex, and Arp2/3-dependent polymerization of actin monomers. Our data reveal distinct strategies for actin-based motility among Burkholderia species.

Original languageEnglish
Pages (from-to)5249-5252
Number of pages4
JournalJournal of Bacteriology
Volume192
Issue number19
DOIs
Publication statusPublished - Oct 2010

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