Actin-binding proteins from Burkholderia mallei and Burkholderia thailandensis can functionally compensate for the actin-based motility defect of a Burkholderia pseudomallei bimA mutant

J M Stevens, R L Ulrich, L A Taylor, M W Wood, D DeShazer, M P Stevens, E E Galyov

Research output: Contribution to journalArticlepeer-review

Abstract

Recently we identified a bacterial factor (BimA) required for actin-based motility of Burkholderia pseudomallei. Here we report that Burkholderia mallei and Burkholderia thailandensis are capable of actin-based motility in J774.2 cells and that BimA homologs of these bacteria can restore the actin-based motility defect of a B. pseudomallei bimA mutant. While the BimA homologs differ in their amino-terminal sequence, they interact directly with actin in vitro and vary in their ability to bind Arp3.

Original languageEnglish
Pages (from-to)7857-7862
Number of pages6
JournalJournal of Bacteriology
Volume187
Issue number22
DOIs
Publication statusPublished - Nov 2005

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