Actin-dependent movement of bacterial pathogens

J M  Stevens; E E  Galyov; M P  Stevens

doi:10.1038/nrmicro1320

Actin-dependent movement of bacterial pathogens

J M Stevens, E E Galyov, M P Stevens

Royal (Dick) School of Veterinary Studies

Research output: Contribution to journal › Literature review › peer-review

Abstract

Listeria, Rickettsia, Burkholderia, Shigella and Mycobacterium species subvert cellular actin dynamics to facilitate their movement within the host cytosol and to infect neighbouring cells while evading host immune surveillance and promoting their intracellular survival. 'Attaching and effacing' Escherichia coli do not enter host cells but attach intimately to the cell surface, inducing motile actin-rich pedestals, the function of which is currently unclear. The molecular basis of actin-based motility of these bacterial pathogens reveals novel insights about bacterial pathogenesis and fundamental host-cell pathways.

Original language	English
Pages (from-to)	91-101
Number of pages	11
Journal	Nature Reviews Microbiology
Volume	4
Issue number	2
DOIs	https://doi.org/10.1038/nrmicro1320
Publication status	Published - Feb 2006

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http://www.nature.com/nrmicro/journal/v4/n2/full/nrmicro1320.html

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title = "Actin-dependent movement of bacterial pathogens",

abstract = "Listeria, Rickettsia, Burkholderia, Shigella and Mycobacterium species subvert cellular actin dynamics to facilitate their movement within the host cytosol and to infect neighbouring cells while evading host immune surveillance and promoting their intracellular survival. 'Attaching and effacing' Escherichia coli do not enter host cells but attach intimately to the cell surface, inducing motile actin-rich pedestals, the function of which is currently unclear. The molecular basis of actin-based motility of these bacterial pathogens reveals novel insights about bacterial pathogenesis and fundamental host-cell pathways.",

author = "Stevens, {J M} and Galyov, {E E} and Stevens, {M P}",

year = "2006",

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AU - Galyov, E E

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AB - Listeria, Rickettsia, Burkholderia, Shigella and Mycobacterium species subvert cellular actin dynamics to facilitate their movement within the host cytosol and to infect neighbouring cells while evading host immune surveillance and promoting their intracellular survival. 'Attaching and effacing' Escherichia coli do not enter host cells but attach intimately to the cell surface, inducing motile actin-rich pedestals, the function of which is currently unclear. The molecular basis of actin-based motility of these bacterial pathogens reveals novel insights about bacterial pathogenesis and fundamental host-cell pathways.

U2 - 10.1038/nrmicro1320

DO - 10.1038/nrmicro1320

M3 - Literature review

SN - 1740-1526

VL - 4

SP - 91

EP - 101

JO - Nature Reviews Microbiology

JF - Nature Reviews Microbiology

IS - 2

ER -

Actin-dependent movement of bacterial pathogens

Abstract

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