Activation of Fas and caspase 3 precedes PrP accumulation in 87V scrapie

E Jamieson, M Jeffrey, J W Ironside, J R Fraser

Research output: Contribution to journalArticlepeer-review

Abstract

The sequence of events involved in the neurodegeneration caused by transmissible spongiform encephalopathies is not yet known. Using a murine scrapie model in which neurodegeneration in the hippocampus is restricted to the CA2, we show an up-regulation of the proapoptotic markers Fas and caspase 3 early in the incubation period prior to disease-specific prion protein (PrP) deposition and clinical signs. These results suggest that activation of Fas and caspase 3 are involved in the early pathological sequence of events during murine scrapie, and that these proapoptotic markers may be a specific method for early detection of neurodegeneration.

Original languageEnglish
Pages (from-to)3567-72
Number of pages6
JournalNeuroreport
Volume12
Issue number16
Publication statusPublished - 16 Nov 2001

Keywords

  • Animals
  • Antigens, CD95
  • Caspase 3
  • Caspases
  • Mice
  • Prions
  • Scrapie
  • Up-Regulation

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