Acute exercise and impaired glucose tolerance in obese humans

Conor McClean, Andrea McNeilly, R. Trinick Tom, Marie Murphy, Ellie Duly, James McLaughlin, Jane McEneny, George Burke, Gareth Davison

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Background: Individuals with impaired glucose tolerance (IGT) have a greater risk of developing diabetes and cardiovascular disease compared to those with normal glycaemic control. The aim of this study was to examine the effects of acute aerobic exercise on glycaemia, regional arterial stiffness and oxidative stress in obese subjects with IGT. Design: Twelve obese subjects (7 males and 5 females; 48.0 ± 9.4 yrs; BMI 32.4 ± 7.0 kg/m2) with IGT participated in a 30 minute bout of walking at 65% of maximum predicted heart rate (HR). Pulse wave velocity (PWV, for determination of arterial stiffness) and blood pressure (BP) were examined pre and post exercise, while venous blood samples were drawn for determination of glucose, blood lipids and indices of oxidative stress and inflammation (lipid hydroperoxides – LOOH; superoxide dismutase – SOD; hs-CRP – high sensitivity C-reactive protein). Results: Post exercise PWV (9.1 ± 1.2 m/sec vs. 8.6 ± 1.0 m/sec), glucose (5.7 ± 0.6 mmol∙L-1 vs. 5.4 ± 0.6 mmol∙L-1) and diastolic BP (94 ± 14 mmHg vs. 86 ± 13 mmHg) decreased, respectively (P 0.05). Conclusions: These findings suggest that acute aerobic exercise can reduce regional arterial stiffness in obese subjects with IGT by possibly improving glucose metabolism, independent of changes in oxidative stress.
Original languageEnglish
Pages (from-to)262-268
Number of pages7
JournalJournal of clinical lipidology
Issue number4
Publication statusPublished - 8 Jul 2009

Keywords / Materials (for Non-textual outputs)

  • Walking
  • Impaired glucose
  • tolerance
  • Regional stiffness
  • Pulse wave velocity
  • Obesity


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