Acute in vivo regulation of 11beta-hydroxysteroid dehydrogenase type 1 activity by insulin and intralipid infusions in humans

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Abstract

Extraadrenal regeneration of cortisol by 11beta-hydroxysteroid dehydrogenase type 1 (11HSD1) is increased after a mixed meal. It is unknown which tissue is responsible and whether this reflects the complex transcriptional control of 11HSD1 or posttranscriptional control exerted by supply of reduced nicotinamide adenine dinucleotide phosphate from hexose-6-phosphate dehydrogenase.
Original languageEnglish
Pages (from-to)4682-8
Number of pages7
JournalJournal of Clinical Endocrinology & Metabolism
Volume91
Issue number11
DOIs
Publication statusPublished - 2006

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