Acute ischemic stroke lesion measurement on diffusion-weighted imaging--important considerations in designing acute stroke trials with magnetic resonance imaging

Carly S Rivers, Joanna M Wardlaw, Paul A Armitage, Mark E Bastin, Peter J Hand, Martin S Dennis

Research output: Contribution to journalArticlepeer-review

Abstract

In acute ischemic stroke, magnetic resonance diffusion-weighted imaging (DWI) is increasingly used to select patients for inclusion or as a surrogate outcome marker in clinical trials, or in routine practice. Little is known of what factors might affect DWI lesion size measurement. We examined morphologic factors that might affect DWI lesion measurement.
Original languageEnglish
Pages (from-to)64-70
Number of pages7
JournalJournal of Stroke and Cerebrovascular Diseases
Volume16
Issue number2
DOIs
Publication statusPublished - 2007

Keywords

  • Acute Disease
  • Adult
  • Aged
  • Aged, 80 and over
  • Bias (Epidemiology)
  • Biological Markers
  • Brain
  • Brain Ischemia
  • Clinical Competence
  • Clinical Trials as Topic
  • Diffusion Magnetic Resonance Imaging
  • Female
  • Humans
  • Male
  • Middle Aged
  • Neuroradiography
  • Neurosciences
  • Observer Variation
  • Outcome Assessment (Health Care)
  • Prospective Studies
  • Reproducibility of Results
  • Research Design
  • Time Factors

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