Adherens junctions connect stress fibres between adjacent endothelial cells

Jaime Millán, Robert J Cain, Natalia Reglero-Real, Carolina Bigarella, Beatriz Marcos-Ramiro, Laura Fernández-Martín, Isabel Correas, Anne J Ridley

Research output: Contribution to journalArticlepeer-review


Endothelial cell-cell junctions maintain endothelial integrity and regulate vascular morphogenesis and homeostasis. Cell-cell junctions are usually depicted with a linear morphology along the boundaries between adjacent cells and in contact with cortical F-actin. However, in the endothelium, cell-cell junctions are highly dynamic and morphologically heterogeneous.
Original languageEnglish
JournalBMC Biology
Publication statusPublished - 2010


  • Actins
  • Adherens Junctions
  • Cadherins
  • Cells, Cultured
  • Endothelial Cells
  • Focal Adhesions
  • Humans
  • Membrane Proteins
  • Microscopy, Electron, Transmission
  • Phosphoproteins
  • RNA, Small Interfering
  • Stress Fibers
  • Tumor Necrosis Factor-alpha
  • Zonula Occludens-1 Protein


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