Adhesion-linked kinases in cancer; emphasis on src, focal adhesion kinase and PI 3-kinase

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Abstract

Our understanding of the complex signal transduction pathways involved in signalling within cancer cells, between cancer cells and between cancer cells and their environment has increased dramatically in recent years. Here we concentrate on three non-receptor kinases: Src, focal adhesion kinase (FAK) and phosphatidylinositol 3-kinase (PI 3-kinase). These form part of a complex network of intracellular signals which is thought to be important in regulating cancer cells.
Original languageEnglish
Pages (from-to)1595-606
Number of pages12
JournalEuropean journal of cancer (Oxford, England : 1990)
Volume36
Issue number13 Spec No
Publication statusPublished - Aug 2000

Keywords

  • Cell Adhesion
  • Cell Communication
  • Cell Division
  • Cell Movement
  • Cell Survival
  • Cytoskeleton
  • Extracellular Matrix
  • Focal Adhesion Kinase 1
  • Focal Adhesion Protein-Tyrosine Kinases
  • Humans
  • Neoplasm Proteins
  • Neoplasms
  • PTEN Phosphohydrolase
  • Phosphatidylinositol 3-Kinases
  • Phosphoric Monoester Hydrolases
  • Protein-Tyrosine Kinases
  • Tumor Suppressor Proteins
  • src-Family Kinases

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