Adipose tissue stem cells: the great WAT hope

William P. Cawthorn, Erica L. Scheller, Ormond A. MacDougald*

*Corresponding author for this work

Research output: Contribution to journalLiterature reviewpeer-review

Abstract

The past decade has witnessed an explosion in research into adipose tissue stem cells (ASCs), facilitated by their ease of isolation from white adipose tissue (WAT) and fueled by their therapeutic potential. Recent developments have extended ASC multipotency to include endodermal and ectodermal cell types, as well as the generation of induced pluripotent stem cells. This expanding multipotency has been paralleled by burgeoning translational applications, ranging from tissue engineering to anti-cancer therapy, that are currently subject to clinical trials. However, this promise is tempered by potential pitfalls, such as tumorigenicity, and is further undermined by lingering uncertainties regarding the precise identity of ASCs. Confronting these issues will be essential if we are to bypass the pitfalls and develop the promises of ASCs.

Original languageEnglish
Pages (from-to)270-277
Number of pages8
JournalTrends in Endocrinology and Metabolism
Volume23
Issue number6
DOIs
Publication statusPublished - Jun 2012

Keywords

  • MESENCHYMAL STROMAL CELLS
  • DIFFERENTIATION IN-VITRO
  • BREAST-CANCER CELLS
  • ACUTE KIDNEY INJURY
  • BONE-MARROW
  • MYOCARDIAL-INFARCTION
  • IMMUNOSUPPRESSIVE PROPERTIES
  • ERECTILE DYSFUNCTION
  • PRECURSOR CELLS
  • PROSTATE TUMOR

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