Adjuvant endocrine therapy for perimenopausal women with early breast cancer

Olaf Ortmann, Tanja Cufer, J Michael Dixon, Nicolai Maass, Paolo Marchetti, Olivia Pagani, Paolo Pronzato, Vladimir Semiglazov, Jean-Philippe Spano, Eduard Vrdoljak, Hans Wildiers

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Adjuvant treatment with aromatase inhibitors (AIs) improves outcomes in postmenopausal women with hormone-sensitive early breast cancer compared with tamoxifen. However, AIs should not be used in premenopausal women because they can paradoxically increase estrogen secretion and may therefore stimulate tumor progression. In perimenopausal women undergoing treatment for breast cancer, it can be difficult to determine true menopausal status because adjuvant chemotherapy, tamoxifen, and gonadotropin-releasing hormone analogues can induce transient (or permanent) ovarian suppression. How can one determine whether these women are truly postmenopausal and therefore candidates for AI therapy? A panel of experts in the field of endocrine therapy in breast cancer met in Dubrovnik, Croatia, on October 23, 2006, to discuss this clinical dilemma. This report summarizes the conclusions and recommendations that arose from this discussion.
Original languageEnglish
Pages (from-to)2-7
Number of pages6
JournalBreast (Edinburgh, Scotland)
Issue number1
Publication statusPublished - Feb 2009

Keywords / Materials (for Non-textual outputs)

  • Adult
  • Antineoplastic Agents, Hormonal
  • Aromatase Inhibitors
  • Breast Neoplasms
  • Chemotherapy, Adjuvant
  • Clinical Trials as Topic
  • Female
  • Humans
  • Middle Aged
  • Neoplasms, Hormone-Dependent
  • Ovariectomy
  • Ovary
  • Patient Selection
  • Perimenopause
  • Postmenopause
  • Tamoxifen


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