ADRENAL-SPECIFIC TRANSGENE EXPRESSION AND DERIVATION OF CONDITIONALLY IMMORTAL RAT ADRENOCORTICAL CELL-LINES

Steven Douglas Morley; I  VIARD; K L  PARKER; John Mullins

ADRENAL-SPECIFIC TRANSGENE EXPRESSION AND DERIVATION OF CONDITIONALLY IMMORTAL RAT ADRENOCORTICAL CELL-LINES

Steven Douglas Morley, I VIARD, K L PARKER, John Mullins

Deanery of Clinical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Conditional immortalisation of cells is a powerful tool for establishing in vitro models maintaining a differentiated phenotype. We are utilising this approach to derive cell lines that maintain the characteristics of glomerulosa and fasciculata cells of the adrenal cortex. Such cell lines should provide a system in which to study aspects of adrenocortical function that are relevant to hypertension, such as the effects of the renin-angiotensin system on steroidogenesis.

Original language	English
Pages (from-to)	353-357
Number of pages	5
Journal	Endocrine research
Volume	21
Issue number	1-2
Publication status	Published - 1995

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title = "ADRENAL-SPECIFIC TRANSGENE EXPRESSION AND DERIVATION OF CONDITIONALLY IMMORTAL RAT ADRENOCORTICAL CELL-LINES",

abstract = "Conditional immortalisation of cells is a powerful tool for establishing in vitro models maintaining a differentiated phenotype. We are utilising this approach to derive cell lines that maintain the characteristics of glomerulosa and fasciculata cells of the adrenal cortex. Such cell lines should provide a system in which to study aspects of adrenocortical function that are relevant to hypertension, such as the effects of the renin-angiotensin system on steroidogenesis.",

author = "Morley, {Steven Douglas} and I VIARD and PARKER, {K L} and John Mullins",

year = "1995",

language = "English",

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journal = "Endocrine research",

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AU - Morley, Steven Douglas

AU - VIARD, I

AU - PARKER, K L

AU - Mullins, John

PY - 1995

Y1 - 1995

N2 - Conditional immortalisation of cells is a powerful tool for establishing in vitro models maintaining a differentiated phenotype. We are utilising this approach to derive cell lines that maintain the characteristics of glomerulosa and fasciculata cells of the adrenal cortex. Such cell lines should provide a system in which to study aspects of adrenocortical function that are relevant to hypertension, such as the effects of the renin-angiotensin system on steroidogenesis.

AB - Conditional immortalisation of cells is a powerful tool for establishing in vitro models maintaining a differentiated phenotype. We are utilising this approach to derive cell lines that maintain the characteristics of glomerulosa and fasciculata cells of the adrenal cortex. Such cell lines should provide a system in which to study aspects of adrenocortical function that are relevant to hypertension, such as the effects of the renin-angiotensin system on steroidogenesis.

M3 - Article

SN - 0743-5800

VL - 21

SP - 353

EP - 357

JO - Endocrine research

JF - Endocrine research

IS - 1-2

ER -

ADRENAL-SPECIFIC TRANSGENE EXPRESSION AND DERIVATION OF CONDITIONALLY IMMORTAL RAT ADRENOCORTICAL CELL-LINES

Abstract

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