ADRENAL-SPECIFIC TRANSGENE EXPRESSION AND DERIVATION OF CONDITIONALLY IMMORTAL RAT ADRENOCORTICAL CELL-LINES

Steven Douglas Morley, I VIARD, K L PARKER, John Mullins

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Conditional immortalisation of cells is a powerful tool for establishing in vitro models maintaining a differentiated phenotype. We are utilising this approach to derive cell lines that maintain the characteristics of glomerulosa and fasciculata cells of the adrenal cortex. Such cell lines should provide a system in which to study aspects of adrenocortical function that are relevant to hypertension, such as the effects of the renin-angiotensin system on steroidogenesis.

Original languageEnglish
Pages (from-to)353-357
Number of pages5
JournalEndocrine research
Volume21
Issue number1-2
Publication statusPublished - 1995

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