Adult intestinal stem cells: critical drivers of epithelial homeostasis and regeneration

Nick Barker

Research output: Contribution to journalLiterature reviewpeer-review

Abstract

Small populations of adult stem cells are responsible for the remarkable ability of the epithelial lining of the intestine to be efficiently renewed and repaired throughout life. The recent discovery of specific markers for these stem cells, together with the development of new technologies to track endogenous stem cell activity in vivo and to exploit their ability to generate new epithelia ex vivo, has greatly improved our understanding of stem cell-driven homeostasis, regeneration and cancer in the intestine. These exciting new insights into the biology of intestinal stem cells have the potential to accelerate the development of stem cell-based therapies and ameliorate cancer treatments.

Original languageEnglish
Pages (from-to)19-33
Number of pages15
JournalNature reviews Molecular cell biology
Volume15
Issue number1
DOIs
Publication statusPublished - Jan 2014

Keywords

  • Adult Stem Cells
  • Animals
  • Cell Lineage
  • Epithelial Cells
  • Homeostasis
  • Humans
  • Intestinal Mucosa
  • Models, Biological
  • Regeneration
  • Stem Cell Niche

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