Advances in IBD genetics

Johan Van Limbergen; Graham Radford-Smith; Jack Satsangi

doi:10.1038/nrgastro.2014.27

Advances in IBD genetics

Johan Van Limbergen, Graham Radford-Smith, Jack Satsangi

Research output: Contribution to journal › Literature review › peer-review

Abstract

IBD is a spectrum of chronic disorders that constitute an important health problem worldwide. The hunt for genetic determinants of disease onset and course has culminated in the Immunochip project, which has identified >160 loci containing IBD susceptibility genes. In this Review, we highlight how genetic association studies have informed our understanding of the pathogenesis of IBD by focusing research efforts on key pathways involved in innate immunity, autophagy, lymphocyte differentiation and chemotaxis. Several of these novel genetic markers and cellular pathways are promising candidates for patient stratification and therapeutic targeting.

Original language	English
Pages (from-to)	372-85
Number of pages	14
Journal	Nature Reviews Gastroenterology & Hepatology
Volume	11
Issue number	6
DOIs	https://doi.org/10.1038/nrgastro.2014.27
Publication status	Published - Jun 2014

Keywords / Materials (for Non-textual outputs)

Humans
Inflammatory Bowel Diseases

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10.1038/nrgastro.2014.27

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title = "Advances in IBD genetics",

abstract = "IBD is a spectrum of chronic disorders that constitute an important health problem worldwide. The hunt for genetic determinants of disease onset and course has culminated in the Immunochip project, which has identified >160 loci containing IBD susceptibility genes. In this Review, we highlight how genetic association studies have informed our understanding of the pathogenesis of IBD by focusing research efforts on key pathways involved in innate immunity, autophagy, lymphocyte differentiation and chemotaxis. Several of these novel genetic markers and cellular pathways are promising candidates for patient stratification and therapeutic targeting.",

keywords = "Humans, Inflammatory Bowel Diseases",

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AB - IBD is a spectrum of chronic disorders that constitute an important health problem worldwide. The hunt for genetic determinants of disease onset and course has culminated in the Immunochip project, which has identified >160 loci containing IBD susceptibility genes. In this Review, we highlight how genetic association studies have informed our understanding of the pathogenesis of IBD by focusing research efforts on key pathways involved in innate immunity, autophagy, lymphocyte differentiation and chemotaxis. Several of these novel genetic markers and cellular pathways are promising candidates for patient stratification and therapeutic targeting.

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KW - Inflammatory Bowel Diseases

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DO - 10.1038/nrgastro.2014.27

M3 - Literature review

C2 - 24614343

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JO - Nature Reviews Gastroenterology & Hepatology

JF - Nature Reviews Gastroenterology & Hepatology

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Advances in IBD genetics

Abstract

Keywords / Materials (for Non-textual outputs)

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