@article{e073369e745245c88807dcb3ec1ef18c,
title = "Advances in Malaria Pharmacology and the online Guide to MALARIA PHARMACOLOGY: IUPHAR review 38",
abstract = "Antimalarial drug discovery has until recently been driven by high-throughput phenotypic cellular screening, allowing millions of compounds to be assayed and delivering clinical drug candidates. In this review, we will focus on target-based approaches, describing recent advances in our understanding of druggable targets in the malaria parasite. Targeting multiple stages of the Plasmodium lifecycle, rather than just the clinically symptomatic asexual blood stage, has become a requirement for new antimalarial medicines, and we link pharmacological data clearly to the parasite stages to which it applies. Finally, we highlight the IUPHAR/MMV Guide to MALARIA PHARMACOLOGY, a web resource developed for the malaria research community that provides open and optimized access to published data on malaria pharmacology.",
author = "Jane Armstrong and Brice Campo and Alexander, {Stephen P H} and Arendse, {Lauren B} and Xiu Cheng and Davenport, {Anthony P} and Elena Faccenda and Fidock, {David A} and Godinez-Macias, {Karla P} and Harding, {Simon D} and Nobutaka Kato and Lee, {Marcus CS} and Luth, {Madeline R} and Ralph Mazitschek and Nimisha Mittal and Niles, {Jacquin C} and John Okombo and Sabine Ottilie and Pasaje, {Charisse Flerida A} and Probst, {Alexandra S} and Mikul Rawat and Frances Rocamora and Tomoyo Sakata-Kato and Christopher Southan and Michael Spedding and Tye, {Mark A} and Tuo Yang and Na Zhao and Davies, {Jamie A}",
note = "Funding Information: The authors wish to thank the British Pharmacological Society (BPS) (MED791) and Medicines for Malaria Venture (MMV) (CT‐5535) for support of the GtoPdb and GtoMPdb. We also acknowledge the contribution made by the Expert Advisory Committee and Scientific Advisors for the GtoMPdb project. This includes the following who are not already authors listed on this manuscript: Jeremy N. Burrows, David R. Cavanagh, Mark J. Coster, F. Javier Gamo, Michael P. Pollastri, Laurent R{\'e}nia, J. Alexandra Rowe, Chris Swain, Matthew H. Todd, Stephen A. Ward and Elizabeth A. Winzeler. LBA gratefully acknowledges the University of Cape Town, the South African Medical Research Council and the Future Leaders − African Independent Research (FLAIR) Fellowship Programme, a partnership between the African Academy of Sciences and the Royal Society funded by the UK Government's Global Challenges Research Fund. Publisher Copyright: {\textcopyright} 2023 The Authors. British Journal of Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society.",
year = "2023",
month = may,
day = "17",
doi = "10.1111/bph.16144",
language = "English",
volume = "180",
pages = "1899--1929",
journal = "British Journal of Pharmacology",
issn = "0007-1188",
publisher = "Nature Publishing Group",
number = "15",
}