Advances in Malaria Pharmacology and the online Guide to MALARIA PHARMACOLOGY: IUPHAR review 38

Jane Armstrong, Brice Campo*, Stephen P H Alexander, Lauren B Arendse, Xiu Cheng, Anthony P Davenport, Elena Faccenda, David A Fidock, Karla P Godinez-Macias, Simon D Harding, Nobutaka Kato, Marcus CS Lee, Madeline R Luth, Ralph Mazitschek, Nimisha Mittal, Jacquin C Niles, John Okombo, Sabine Ottilie, Charisse Flerida A Pasaje, Alexandra S ProbstMikul Rawat, Frances Rocamora, Tomoyo Sakata-Kato, Christopher Southan, Michael Spedding, Mark A Tye, Tuo Yang, Na Zhao, Jamie A Davies*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Antimalarial drug discovery has until recently been driven by high-throughput phenotypic cellular screening, allowing millions of compounds to be assayed and delivering clinical drug candidates. In this review, we will focus on target-based approaches, describing recent advances in our understanding of druggable targets in the malaria parasite. Targeting multiple stages of the Plasmodium lifecycle, rather than just the clinically symptomatic asexual blood stage, has become a requirement for new antimalarial medicines, and we link pharmacological data clearly to the parasite stages to which it applies. Finally, we highlight the IUPHAR/MMV Guide to MALARIA PHARMACOLOGY, a web resource developed for the malaria research community that provides open and optimized access to published data on malaria pharmacology.
Original languageEnglish
Pages (from-to)1899-1929
JournalBritish Journal of Pharmacology
Issue number15
Early online date17 May 2023
Publication statusE-pub ahead of print - 17 May 2023


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