Projects per year
Abstract / Description of output
Introduction: Immune checkpoint inhibitors and adoptive T-cell therapy based on chimeric antigen receptors are the spearhead strategies to exploit the immune system to fight cancer. To take advantage of the full potential of the immune system, cancer immunotherapy must incorporate new biotechnologies such as mRNA technology that may synergize with already approved immunotherapies and act more effectively on immune targets.
Areas covered: This review describes the basics of mRNA biotechnology and provides insight into the recent advances in the use of mRNA for the local and systemic delivery of immunostimulatory antibodies, proinflammatory cytokines or for optimizing adoptive T-cell therapy.
Expert opinion: mRNA-based nanomedicines have great potential to expand the arsenal of immunotherapy tools due to their ability to simplify and accelerate drug development and their suitability for transient and local expression of immunostimulatory molecules, whose systemic and sustained expression would be toxic. The success of mRNA-based COVID-19 vaccines has highlighted the feasibility of this approach. Continuous advances in the delivery and construction of RNA-based vectors hold promise for improvements in clinical efficacy.
Original language | English |
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Number of pages | 46 |
Journal | Expert opinion on drug discovery |
Early online date | 20 Sept 2021 |
DOIs | |
Publication status | E-pub ahead of print - 20 Sept 2021 |
Keywords / Materials (for Non-textual outputs)
- adoptive T-cell transfer
- bispecific antibodies
- chimeric antigen receptor
- Cytokines
- lipid nanoparticles
- mRNA
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Dive into the research topics of 'Advances in mRNA-based drug discovery in cancer immunotherapy'. Together they form a unique fingerprint.Projects
- 1 Finished
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Training Network for the education of the next generation scientist in targeting the supressive capacity of regulatory T-cells specifically within tumours
Zaiss, D.
1/06/18 → 30/11/22
Project: Research