Abstract / Description of output
Cellular movement is central to invasion. The Rho family of small GTPases co-ordinate the cytoskeletal and adhesion modelling within cells that is crucial for normal migratory responses. Consequently, Rho proteins, and their regulators and effectors, are targets for subversion during oncogenic transformation and tumour development. Recent findings have thrown light on how actin regulators may be linked to oncogenesis and the development of cancer.
| Original language | English |
|---|---|
| Pages (from-to) | 36-43 |
| Number of pages | 8 |
| Journal | Current Opinion in Genetics and Development |
| Volume | 12 |
| Issue number | 1 |
| Publication status | Published - Feb 2002 |
Keywords / Materials (for Non-textual outputs)
- Actin Cytoskeleton
- Actins
- Animals
- Cell Adhesion
- Cell Movement
- Cell Size
- Cell Transformation, Neoplastic
- Humans
- Integrins
- Models, Biological
- Neoplasm Invasiveness
- Neoplasm Metastasis
- Signal Transduction
- rho GTP-Binding Proteins