Adverse-Mode FFF: Multi-Force Ideal Retention Theory

Tyler Shendruk, Gary W Slater

Research output: Contribution to journalArticlepeer-review


A novel field-flow fractionation (FFF) technique, in which two opposing external forces act on the solute particles, is proposed. When the two external forces are sufficiently strong and scale differently as a function of the solutes’ property of interest (such as the solute particle size), a sharp peak in the retention ratio (dramatic drop in elution time) is predicted to exist. Because the external forces oppose one another, we refer to this novel technique as adverse-mode FFF. The location of this peak is theoretically predicted and its ideal width estimated. The peak can become quite sharp by simultaneously increasing the strength of both fields, suggesting that adverse-mode FFF could be a useful technique for accurately measuring single species solute size
Original languageEnglish
Pages (from-to)392-409
Number of pages18
Issue number2
Publication statusPublished - 7 Jul 2015

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