Aerobic fitness is associated with lower proportions of senescent blood T-cells in man

Guillaume Spielmann, Brian K McFarlin, Daniel P O'Connor, Paula J W Smith, Hanspeter Pircher, Richard J Simpson

Research output: Contribution to journalArticlepeer-review

Abstract

Senescent T-cells accumulate with age, lowering the naïve T-cell repertoire and increasing host infection risk. As this response is likely to be influenced by certain lifestyle factors, we examined the association between aerobic fitness (VO(2max)) and the age-related accumulation of senescent T-cells. Blood lymphocytes from 102 healthy males (18-61 yr) were analyzed for KLRG1, CD57, CD28, CD45RA, CD45RO surface expression on CD4+ and CD8+ T-cells by 4-color flow cytometry. Advancing age (yr) was positively associated with the proportion (%) of senescent (KLRG1+/CD57+; KLRG1+/CD28-) CD4+ (B=1.00; 1.02) and CD8+ (B=0.429; 1.02) T-cells and inversely associated with naïve (KLRG1-/CD28+) CD4+ (B=-1.000) and CD8+ (B=-0.993) T-cells. VO(2max) was inversely associated with senescent CD4+ (B=-0.97) and CD8+ (B=-0.240). Strikingly, age was no longer associated with the proportions of senescent or naïve T-cells after adjusting for VO(2max), while the association between VO(2max) and these T-cell subsets withstood adjustment for age, BMI and percentage body fat. Ranking participants by age-adjusted VO(2max) revealed that the highest tertile had 17% more naïve CD8+ T-cells and 57% and 37% less senescent CD4+ and CD8+ T-cells, respectively, compared to the lowest tertile. VO(2max) was not associated with latent cytomegalovirus (CMV), Epstein-Barr virus (EBV) or herpes simplex virus-1 (HSV-1) infection, indicating that the moderating associations of VO(2max) were not confounded by persistent viral infections. This is the first study to show that aerobic fitness is associated with a lower age-related accumulation of senescent T-cells, highlighting the beneficial effects of maintaining a physically active lifestyle on the aging immune system.

Original languageEnglish
Pages (from-to)1521-9
Number of pages9
JournalBrain, Behavior, and Immunity
Volume25
Issue number8
DOIs
Publication statusPublished - Nov 2011

Keywords

  • Adolescent
  • Adult
  • Anaerobic Threshold
  • Antigens, Surface
  • Body Composition
  • Body Mass Index
  • Cellular Senescence
  • Cytomegalovirus Infections
  • Epstein-Barr Virus Infections
  • Exercise
  • Flow Cytometry
  • Herpes Simplex
  • Humans
  • Male
  • Middle Aged
  • Monocytes
  • Motor Activity
  • Physical Fitness
  • Regression Analysis
  • T-Lymphocytes
  • Young Adult
  • Journal Article

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