African trypanosomes

Mathieu Cayla, Federico Rojas, Eleanor Silvester, Frank Venter, Keith R. Matthews

Research output: Contribution to journalArticlepeer-review

Abstract

African trypanosomes cause human African trypanosomiasis and animal African trypanosomiasis. They are transmitted by tsetse flies in sub-Saharan Africa. Although most famous for their mechanisms of immune evasion by antigenic variation, there have been recent important studies that illuminate important aspects of the biology of these parasites both in their mammalian host and during passage through their tsetse fly vector. This Primer overviews current research themes focused on these parasites and discusses how these biological insights and the development of new technologies to interrogate gene function are being used in the search for new approaches to control the parasite. The new insights into the biology of trypanosomes in their host and vector highlight that we are in a ‘golden age’ of discovery for these fascinating parasites.
Original languageEnglish
Article number190
Number of pages8
JournalParasites and Vectors
Volume12
Issue number1
Early online date29 Apr 2019
DOIs
Publication statusE-pub ahead of print - 29 Apr 2019

Keywords

  • Trypanosoma brucei
  • Sleeping sickness
  • Trypanosome

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