Age at onset in two common neurodegenerative diseases is genetically controlled

Yi-Ju Li, William K. Scott, Dale J. Hedges, Fengyu Zhang, P. Craig Gaskell, Martha A Nance, Ray L Watts, Jean P Hubble, William C Koller, Rajesh Pahwa, Matthew B Stern, Bradley C Hiner, Joseph Jankovic, Fred H Allen, Christopher G Goetz, Frank Mastaglia, Jeffrey M Stajich, Rachel A. Gibson, Lefkos T Middleton, Ann M SaundersBurton L Scott, Gary W. Small, Kristin K. Nicodemus, Allison D. Reed, Donald E Schmechel, Kathleen A Welsh-Bohmer, P. Michael Conneally, Allen D Roses, John R Gilbert, Jeffery M. Vance, Jonathan L Haines, Margaret A Pericak-Vance

Research output: Contribution to journalArticlepeer-review

Abstract

To identify genes influencing age at onset (AAO) in two common neurodegenerative diseases, a genomic screen was performed for AAO in families with Alzheimer disease (AD; n = 449) and Parkinson disease (PD; n = 174). Heritabilities between 40%-60% were found in both the AD and PD data sets. For PD, significant evidence for linkage to AAO was found on chromosome 1p (LOD = 3.41). For AD, the AAO effect of APOE (LOD = 3.28) was confirmed. In addition, evidence for AAO linkage on chromosomes 6 and 10 was identified independently in both the AD and PD data sets. Subsequent unified analyses of these regions identified a single peak on chromosome 10q between D1051239 and D1051237, with a maximum LOD score of 2.62. These data suggest that a common gene affects AAO in these two common complex neurodegenerative diseases.

Original languageEnglish
Pages (from-to)985-993
Number of pages9
JournalAmerican Journal of Human Genetics
Volume70
Issue number4
DOIs
Publication statusPublished - 2002

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