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Abstract / Description of output
Aging is associated with functional activation changes in domain-specific regions and large-scale brain networks. This preregistered Functional magnetic resonance imaging (fMRI) study investigated these effects within the domain of semantic cognition. Participants completed 1 nonsemantic and 2 semantic tasks. We found no age differences in semantic activation in core semantic regions. However, the right inferior frontal gyrus showed difficulty-related increases in both age groups. This suggests that age-related upregulation of this area may be a compensatory response to increased processing demands. At a network level, older people showed more engagement in the default mode network and less in the executive multiple-demand network, aligning with older people’s greater knowledge reserves and executive declines. In contrast, activation was age-invariant in semantic control regions. Finally, older adults showed reduced demand-related modulation of multiple-demand network activation in the nonsemantic task but not the semantic tasks. These findings provide a new perspective on the neural basis of semantic cognition in aging, suggesting that preserved function in specialized semantic networks may help to maintain semantic cognition in later life.
|Number of pages||18|
|Journal||Neurobiology of Aging|
|Early online date||25 Jul 2023|
|Publication status||Published - Nov 2023|
Keywords / Materials (for Non-textual outputs)
- semantic cognition
- cognitive ageing
- executive function
- inferior frontal gyrus
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- 1 Finished
7/09/20 → 6/09/23