Projects per year
Abstract / Description of output
Gene expression is influenced by both genetic variants and the environment. As individuals age, changes in gene expression may be associated with decline in physical and cognitive abilities. We measured transcriptome-wide expression levels in lymphoblastoid cell lines derived from members of the Lothian Birth Cohort 1936 at mean ages 70 and 76 years. Changes in gene expression levels were identified for 1,741 transcripts in 434 individuals. Gene Ontology enrichment analysis indicated an enrichment of biological processes involved in the immune system. Transcriptome-wide association analysis was performed for eleven cognitive, fitness, and biomedical aging-related traits at age 70 years (N=665 to 781) and with mortality. Transcripts for genes (F2RL3, EMILIN1 and CDC42BPA) previously identified as being differentially methylated or expressed in smoking or smoking-related cancers were overexpressed in smokers compared to non-smokers and the expression of transcripts for genes (HERPUD1, GAB2, FAM167A and GLS) previously associated with stress response, autoimmune disease and cancer were associated with telomere length. No associations between expression levels and other traits, or mortality were identified.
Original language | English |
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Pages (from-to) | 2489-2503 |
Number of pages | 15 |
Journal | Aging |
Volume | 9 |
Issue number | 12 |
DOIs | |
Publication status | Published - 1 Dec 2017 |
Keywords / Materials (for Non-textual outputs)
- cognitive
- physical
- gene expression
- methylation
- telomeres
- smoking
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Dive into the research topics of 'Age-related gene expression changes, and transcriptome wide association study of physical and cognitive aging traits, in the Lothian Birth Cohort 1936'. Together they form a unique fingerprint.Projects
- 3 Finished
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Brain imaging and cognitive ageing in the Lothian Birth Cohort 1936: III
Wardlaw, J., Bastin, M. & Deary, I.
1/05/15 → 30/04/19
Project: Research
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RA2661 Centre for Cognitive Ageing and Cognitive Epidemiology Phase 2. Main Budget.
Deary, I., Gale, C., Holmes, M., Logie, P., Maclullich, A., Porteous, D., Seckl, J., Starr, J., Wardlaw, J. & Okely, J.
1/09/13 → 31/08/19
Project: Research
Profiles
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Sarah Harris
- School of Philosophy, Psychology and Language Sciences - Senior Research Fellow
- Edinburgh Neuroscience
Person: Academic: Research Active