Age-related respiratory responses to substance P in normal sheep

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

The in vivo effects of substance P (SP) on respiratory parameters in four different age groups of sheep were examined. Intravenous SP (10(-8) to 5 x 10(-6) mol kg-1 bodyweight) caused a dose-dependent reduction in dynamic compliance and increase in respiratory resistance in all four groups. The bronchoconstrictor response was age-related, with the greatest response occurring in the youngest age group (four to six months). In the oldest group (over four years) there was minimal bronchomotor response to SP, but a dose-dependent apnoea was present. These findings indicate that there is an age-related alteration in the respiratory response to SP in sheep.
Original languageEnglish
Pages (from-to)130-2
Number of pages3
JournalResearch in Veterinary Science
Issue number1
Publication statusPublished - Jan 1993

Keywords / Materials (for Non-textual outputs)

  • Aging
  • Animals
  • Female
  • Respiration
  • Sheep
  • Substance P


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