Alarming dendritic cells for Th2 induction

Andrew S MacDonald, Rick M Maizels

Research output: Contribution to journalArticlepeer-review

Abstract

There is an ever-increasing understanding of the mechanisms by which pathogens such as bacteria, viruses, and protozoa activate dendritic cells (DCs) to drive T helper type 1 (Th1) responses, but we know much less about how these cells elicit Th2 responses. This gap in our knowledge puts us at a distinct disadvantage in designing therapeutics for certain immune-mediated diseases. However, progress is being made with the identification of novel endogenous tissue factors that can enhance Th2 induction by DCs.
Original languageEnglish
Pages (from-to)13-7
Number of pages5
JournalJournal of Experimental Medicine
Volume205
Issue number1
DOIs
Publication statusPublished - Jan 2008

Keywords

  • Animals
  • Binding, Competitive
  • Cell Differentiation
  • Cytokines
  • Dendritic Cells
  • Humans
  • Immune System
  • Ligands
  • Models, Biological
  • Th1 Cells
  • Th2 Cells

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