Abstract
There is an ever-increasing understanding of the mechanisms by which pathogens such as bacteria, viruses, and protozoa activate dendritic cells (DCs) to drive T helper type 1 (Th1) responses, but we know much less about how these cells elicit Th2 responses. This gap in our knowledge puts us at a distinct disadvantage in designing therapeutics for certain immune-mediated diseases. However, progress is being made with the identification of novel endogenous tissue factors that can enhance Th2 induction by DCs.
| Original language | English |
|---|---|
| Pages (from-to) | 13-7 |
| Number of pages | 5 |
| Journal | Journal of Experimental Medicine |
| Volume | 205 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 2008 |
Keywords / Materials (for Non-textual outputs)
- Animals
- Binding, Competitive
- Cell Differentiation
- Cytokines
- Dendritic Cells
- Humans
- Immune System
- Ligands
- Models, Biological
- Th1 Cells
- Th2 Cells
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