Abstract / Description of output
Twenty per cent of cervical intraepithelial neoplasias-III (CIN-III) progress to invasive cancer. Human papillomavirus (HPV) infection alone does not determine progression. CIN-III lesions were collected from 161 women. Each tissue was microdissected into a maximum of 32 contiguous units and assayed at multiple microsatellite loci on chromosome 11q, a region frequently deleted in invasive cervical and other cancers. Eight of 108 informative cases (7%) had 11q23.3-q25 deletions; focally intra-lesional in six (one with focal loss of alternate alleles), and pan-lesional in two cases. Hence, 11q deletion can occur early in cervical neoplasia, and possibly predisposes to invasion.
Original language | English |
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Pages (from-to) | 2557-64 |
Number of pages | 8 |
Journal | Oncogene |
Volume | 16 |
Issue number | 19 |
DOIs | |
Publication status | Published - 14 May 1998 |
Keywords / Materials (for Non-textual outputs)
- Adolescent
- Adult
- Alleles
- Cervical Intraepithelial Neoplasia
- Chromosome Deletion
- Chromosomes, Human, Pair 11
- Female
- Humans
- Loss of Heterozygosity
- Middle Aged
- Oncogene Proteins, Viral
- Papillomavirus E7 Proteins
- Repressor Proteins