Allelic deletion at 11q23.3-q25 is an early event in cervical neoplasia

M F Evans, J Koreth, C J Bakkenist, C S Herrington, J O McGee

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Twenty per cent of cervical intraepithelial neoplasias-III (CIN-III) progress to invasive cancer. Human papillomavirus (HPV) infection alone does not determine progression. CIN-III lesions were collected from 161 women. Each tissue was microdissected into a maximum of 32 contiguous units and assayed at multiple microsatellite loci on chromosome 11q, a region frequently deleted in invasive cervical and other cancers. Eight of 108 informative cases (7%) had 11q23.3-q25 deletions; focally intra-lesional in six (one with focal loss of alternate alleles), and pan-lesional in two cases. Hence, 11q deletion can occur early in cervical neoplasia, and possibly predisposes to invasion.

Original languageEnglish
Pages (from-to)2557-64
Number of pages8
JournalOncogene
Volume16
Issue number19
DOIs
Publication statusPublished - 14 May 1998

Keywords / Materials (for Non-textual outputs)

  • Adolescent
  • Adult
  • Alleles
  • Cervical Intraepithelial Neoplasia
  • Chromosome Deletion
  • Chromosomes, Human, Pair 11
  • Female
  • Humans
  • Loss of Heterozygosity
  • Middle Aged
  • Oncogene Proteins, Viral
  • Papillomavirus E7 Proteins
  • Repressor Proteins

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