Allelic variations of the multidrug resistance gene determine susceptibility and disease behavior in ulcerative colitis

Gwo-Tzer Ho, Elaine R Nimmo, Albert Tenesa, Janice Fennell, Hazel Drummond, Craig Mowat, Ian D Arnott, Jack Satsangi

Research output: Contribution to journalArticlepeer-review

Abstract

The MDR1 gene encodes P-glycoprotein 170, an efflux transporter that is highly expressed in intestinal epithelial cells. The MDR1 exonic single nucleotide polymorphisms (SNPs) C3435T and G2677T have been shown to correlate with activity/expression of P-glycoprotein 170.
Original languageEnglish
Pages (from-to)288-96
Number of pages9
JournalGastroenterology
Volume128
Issue number2
Publication statusPublished - Feb 2005

Keywords

  • Adolescent
  • Adult
  • Age of Onset
  • Colitis, Ulcerative
  • Crohn Disease
  • Exons
  • Female
  • Genes, MDR
  • Genetic Variation
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • Phenotype
  • Polymorphism, Single Nucleotide

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