Allergen immunotherapy for the prevention of allergic disease: Protocol for a systematic review

Sangeeta Dhami*, Ulugbek Nurmatov, Susanne Halken, Moises A. Calderón, Antonella Muraro, Graham Roberts, George Du Toit, Jörg Kleine-Tebbe, Desiree Larenas-Linnemann, Susanne Lau, Paolo Maria Matricardi, Giovanni Pajno, Nikolaos G. Papadopoulos, Oliver Pfaar, Dermot Ryan, Alexandra F. Santos, Frans Timmermanns, Ulrich Wahn, Aziz Sheikh

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Background: The European Academy of Allergy and Clinical Immunology (EAACI) is in the process of developing the EAACI Guidelines for Allergen Immunotherapy (AIT) for the Prevention of Allergic Disease. We seek to critically assess the effectiveness, cost-effectiveness, and safety of AIT in the prevention of allergic disease. Methods: We will undertake a systematic review, which will involve searching international biomedical databases for published, in progress and unpublished evidence. Studies will be independently screened against pre-defined eligibility criteria and critically appraised using established instruments. Data will be descriptively and, if possible and appropriate, quantitatively synthesized. Discussion: The findings from this review will be used to inform the development of recommendations for EAACI's Guidelines on AIT.

Original languageEnglish
JournalPediatric Allergy and Immunology
Early online date21 Jan 2016
Publication statusPublished - May 2016


  • Allergen immunotherapy
  • Allergic diseases
  • Allergy
  • Atopic
  • Prevention
  • Sensitization


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