Alpha-synuclein RT-QuIC in the CSF of patients with alpha-synucleinopathies

Graham Fairfoul , Lynne I McGuire, Suvankar Pal, James Ironside, Juliane Neumann, Sharon Christie, Catherine Joachim, Margaret Esiri, Samuel G Evetts, Michal Rolinski, Fahd Baig, Claudio Ruffmann, Richard Wade-Martins, Michele T M Hu, Laura Parkkinen, Alison Green

Research output: Contribution to journalArticlepeer-review

Abstract

We have developed a novel real-time quaking induced conversion RT-QuIC based assay to detect alpha-synuclein aggregation in brain and CSF from Dementia with Lewy bodies (DLB) and Parkinson’s disease (PD) patients. This assay can detect alpha-synuclein aggregation in DLB and PD CSF with sensitivities of 92% and 95%, respectively and with an overall specificity of 100% when compared to Alzheimer (AD) and control CSF. Patients with neuropathologically confirmed tauopathies (PSP, CBD) gave negative results. These results suggest that RT-QuiC analysis of CSF is potentially useful for the early clinical assessment of patients with alpha-synucleinopathies
Original languageEnglish
JournalAnnals of Clinical and Translational Neurology
Early online date28 Aug 2016
DOIs
Publication statusE-pub ahead of print - 28 Aug 2016

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