Alpha/beta and gamma interferons are induced by infection with noncytopathic bovine viral diarrhea virus in vivo

B Charleston, L.S Brackenbury, B V Carr, M D Fray, Jayne Hope, CJ Howard, Ivan Morrison

Research output: Contribution to journalArticlepeer-review

Abstract

In contrast to the results of previous in vitro studies, experimental infection of calves with noncytopathic bovine viral diarrhea virus (ncpBVDV) was found to induce strong alpha/beta and gamma interferon responses in gnotobiotic animals. These responses were associated with depressed levels of transforming growth factor beta (TGF-beta) in serum. The results of this study indicate that the immunosuppression caused by ncpBVDV is not associated with low interferon responses or elevated levels of TGF-beta.
Original languageEnglish
Pages (from-to)923-7
Number of pages5
JournalJ Virol
Volume76
Issue number2
DOIs
Publication statusPublished - Jan 2002

Keywords

  • Acute Disease
  • Animals
  • Bovine Virus Diarrhea-Mucosal Disease/immunology
  • Bovine Virus Diarrhea-Mucosal Disease/pathology
  • Cattle
  • Cell Division
  • Diarrhea Viruses, Bovine Viral/pathogenicity
  • Diarrhea Viruses, Bovine Viral/physiology
  • Immune Tolerance/immunology
  • Interferons/biosynthesis
  • Interferons/immunology
  • Kinetics
  • Mycobacterium bovis/immunology
  • Transforming Growth Factor beta/blood

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