Alteration in lymphocyte responses, cytokine and chemokine profiles in chickens infected with genotype VII and VIII velogenic Newcastle disease virus

Mehdi Rasoli, Swee Keong Yeap, Sheau Wei Tan, Hassan Moeini, Aini Ideris, Mohd Hair Bejo, Noorjahan Banu Mohamed Alitheen, Pete Kaiser, Abdul Rahman Omar

Research output: Contribution to journalArticlepeer-review

Abstract

Newcastle disease (ND) is a highly contagious avian disease and one of the major causes of economic losses in the poultry industry. The emergence of virulent NDV genotypes and repeated outbreaks of NDV in vaccinated chickens have raised the need for fundamental studies on the virus-host interactions. In this study, the profiles of B and T lymphocytes and macrophages and differential expression of 26 immune-related genes in the spleen of specific-pathogen-free (SPF) chickens, infected with either the velogenic genotype VII NDV strain IBS002 or the genotype VIII NDV strain AF2240, were evaluated. A significant reduction in T lymphocyte population and an increase in the infiltration of IgM(+) B cells and KUL01(+) macrophages were detected in the infected spleens at 1, 3 and 4 days post-infection (dpi) (P
Original languageEnglish
Pages (from-to)11-21
JournalComparative Immunology, Microbiology and Infectious Diseases
Volume37
Issue number1
Early online date19 Oct 2013
DOIs
Publication statusPublished - 2014

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