Alterations in PTEN and PIK3CA in colorectal cancers in the EPIC Norfolk study: associations with clinicopathological and dietary factors

Adam Naguib, James C Cooke, Lisa Happerfield, Lucy Kerr, Laura J Gay, Robert N Luben, Richard Y Ball, Panagiota N Mitrou, Alison McTaggart, Mark J Arends

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

The PTEN tumour suppressor gene and PIK3CA proto-oncogene encode proteins which contribute to regulation and propagation of signal transduction through the PI3K/AKT signalling pathway. This study investigates the prevalence of loss of PTEN expression and mutations in both PTEN and PIK3CA in colorectal cancers (CRC) and their associations with tumour clinicopathological features, lifestyle factors and dietary consumptions.
Original languageEnglish
Pages (from-to)123
JournalBMC Cancer
Volume11
DOIs
Publication statusPublished - 2011

Keywords / Materials (for Non-textual outputs)

  • Adenocarcinoma
  • Aged
  • Aged, 80 and over
  • Colonic Neoplasms
  • DNA Mutational Analysis
  • Disease Progression
  • Female
  • Gene Expression Regulation, Neoplastic
  • Genetic Association Studies
  • Humans
  • Immunohistochemistry
  • Male
  • Middle Aged
  • Mutation
  • PTEN Phosphohydrolase
  • Phosphatidylinositol 3-Kinases
  • Questionnaires
  • Sex Factors

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