Altered muscle development and expression of the insulin-like growth factor system in growth retarded fetal pigs

R E Tilley; C J McNeil; C J Ashworth; K R Page; H J McArdle

doi:10.1016/j.domaniend.2006.02.003

Altered muscle development and expression of the insulin-like growth factor system in growth retarded fetal pigs

R E Tilley, C J McNeil, C J Ashworth, K R Page, H J McArdle

Royal (Dick) School of Veterinary Studies

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

We have used a porcine model of spontaneous differential fetal growth to investigate the effects of fetal size on muscle development. We hypothesized that altered muscle development may occur in small fetuses as a consequence of modified expression of selected genes of the insulin-like growth factor system. We examined the development of the Longissimus muscle (m. Longissimus) in small fetuses and their average sized littermates. We collected small for gestational age fetuses and their average sized sibling on days 45, 65 and 100 of gestation (term is 113-116 days). Small fetuses had significantly lower body weight at all three stages of gestation (p

Original language	English
Pages (from-to)	167-77
Number of pages	11
Journal	Domestic Animal Endocrinology
Volume	32
Issue number	3
DOIs	https://doi.org/10.1016/j.domaniend.2006.02.003
Publication status	Published - Apr 2007

Keywords / Materials (for Non-textual outputs)

Animals
Female
Fetal Growth Retardation
Fetal Weight
Fetus
Gene Expression Regulation, Developmental
Insulin-Like Growth Factor Binding Protein 3
Insulin-Like Growth Factor Binding Protein 5
Insulin-Like Growth Factor Binding Proteins
Insulin-Like Growth Factor I
Insulin-Like Growth Factor II
Muscle Development
Muscle Fibers, Skeletal
Muscle, Skeletal
Myogenin
Pregnancy
Receptor, IGF Type 1
Receptor, IGF Type 2
Sus scrofa

Access to Document

10.1016/j.domaniend.2006.02.003

Cite this

@article{5cb8d54250274bd2984c893f7ace8074,

title = "Altered muscle development and expression of the insulin-like growth factor system in growth retarded fetal pigs",

abstract = "We have used a porcine model of spontaneous differential fetal growth to investigate the effects of fetal size on muscle development. We hypothesized that altered muscle development may occur in small fetuses as a consequence of modified expression of selected genes of the insulin-like growth factor system. We examined the development of the Longissimus muscle (m. Longissimus) in small fetuses and their average sized littermates. We collected small for gestational age fetuses and their average sized sibling on days 45, 65 and 100 of gestation (term is 113-116 days). Small fetuses had significantly lower body weight at all three stages of gestation (p",

keywords = "Animals, Female, Fetal Growth Retardation, Fetal Weight, Fetus, Gene Expression Regulation, Developmental, Insulin-Like Growth Factor Binding Protein 3, Insulin-Like Growth Factor Binding Protein 5, Insulin-Like Growth Factor Binding Proteins, Insulin-Like Growth Factor I, Insulin-Like Growth Factor II, Muscle Development, Muscle Fibers, Skeletal, Muscle, Skeletal, Myogenin, Pregnancy, Receptor, IGF Type 1, Receptor, IGF Type 2, Sus scrofa",

author = "Tilley, {R E} and McNeil, {C J} and Ashworth, {C J} and Page, {K R} and McArdle, {H J}",

year = "2007",

month = apr,

doi = "10.1016/j.domaniend.2006.02.003",

language = "English",

volume = "32",

pages = "167--77",

journal = "Domestic Animal Endocrinology",

issn = "0739-7240",

publisher = "Elsevier",

number = "3",

}

TY - JOUR

T1 - Altered muscle development and expression of the insulin-like growth factor system in growth retarded fetal pigs

AU - Tilley, R E

AU - McNeil, C J

AU - Ashworth, C J

AU - Page, K R

AU - McArdle, H J

PY - 2007/4

Y1 - 2007/4

N2 - We have used a porcine model of spontaneous differential fetal growth to investigate the effects of fetal size on muscle development. We hypothesized that altered muscle development may occur in small fetuses as a consequence of modified expression of selected genes of the insulin-like growth factor system. We examined the development of the Longissimus muscle (m. Longissimus) in small fetuses and their average sized littermates. We collected small for gestational age fetuses and their average sized sibling on days 45, 65 and 100 of gestation (term is 113-116 days). Small fetuses had significantly lower body weight at all three stages of gestation (p

AB - We have used a porcine model of spontaneous differential fetal growth to investigate the effects of fetal size on muscle development. We hypothesized that altered muscle development may occur in small fetuses as a consequence of modified expression of selected genes of the insulin-like growth factor system. We examined the development of the Longissimus muscle (m. Longissimus) in small fetuses and their average sized littermates. We collected small for gestational age fetuses and their average sized sibling on days 45, 65 and 100 of gestation (term is 113-116 days). Small fetuses had significantly lower body weight at all three stages of gestation (p

KW - Animals

KW - Female

KW - Fetal Growth Retardation

KW - Fetal Weight

KW - Fetus

KW - Gene Expression Regulation, Developmental

KW - Insulin-Like Growth Factor Binding Protein 3

KW - Insulin-Like Growth Factor Binding Protein 5

KW - Insulin-Like Growth Factor Binding Proteins

KW - Insulin-Like Growth Factor I

KW - Insulin-Like Growth Factor II

KW - Muscle Development

KW - Muscle Fibers, Skeletal

KW - Muscle, Skeletal

KW - Myogenin

KW - Pregnancy

KW - Receptor, IGF Type 1

KW - Receptor, IGF Type 2

KW - Sus scrofa

U2 - 10.1016/j.domaniend.2006.02.003

DO - 10.1016/j.domaniend.2006.02.003

M3 - Article

C2 - 16564666

SN - 0739-7240

VL - 32

SP - 167

EP - 177

JO - Domestic Animal Endocrinology

JF - Domestic Animal Endocrinology

IS - 3

ER -

Altered muscle development and expression of the insulin-like growth factor system in growth retarded fetal pigs

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

Access to Document

Fingerprint

Cite this