Altered patterns of gene expression underlying the enhanced immunogenicity of radiation-attenuated schistosomes

Gary P Dillon; Theresa Feltwell; Jason Skelton; Patricia S Coulson; R Alan Wilson; Alasdair C Ivens

doi:10.1371/journal.pntd.0000240

Altered patterns of gene expression underlying the enhanced immunogenicity of radiation-attenuated schistosomes

Gary P Dillon, Theresa Feltwell, Jason Skelton, Patricia S Coulson, R Alan Wilson, Alasdair C Ivens

School of Biological Sciences

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

Schistosome cercariae only elicit high levels of protective immunity against a challenge infection if they are optimally attenuated by exposure to ionising radiation that truncates their migration in the lungs. However, the underlying molecular mechanisms responsible for the altered phenotype of the irradiated parasite that primes for protection have yet to be identified.

Original language	English
Pages (from-to)	e240
Journal	PLoS Neglected Tropical Diseases
Volume	2
Issue number	5
DOIs	https://doi.org/10.1371/journal.pntd.0000240
Publication status	Published - 21 May 2008

Keywords / Materials (for Non-textual outputs)

Snails
Polymerase Chain Reaction
Animals
Schistosoma
Mice
Gene Expression Regulation
Immunity
Genes, Helminth
Time Factors
Antigens, Helminth

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10.1371/journal.pntd.0000240

Altered patterns of gene expression underlying the enhanced immunogenicity of radiation-attenuated schistosomes
This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Cite this

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title = "Altered patterns of gene expression underlying the enhanced immunogenicity of radiation-attenuated schistosomes",

abstract = "Schistosome cercariae only elicit high levels of protective immunity against a challenge infection if they are optimally attenuated by exposure to ionising radiation that truncates their migration in the lungs. However, the underlying molecular mechanisms responsible for the altered phenotype of the irradiated parasite that primes for protection have yet to be identified.",

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AU - Wilson, R Alan

AU - Ivens, Alasdair C

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AB - Schistosome cercariae only elicit high levels of protective immunity against a challenge infection if they are optimally attenuated by exposure to ionising radiation that truncates their migration in the lungs. However, the underlying molecular mechanisms responsible for the altered phenotype of the irradiated parasite that primes for protection have yet to be identified.

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KW - Polymerase Chain Reaction

KW - Animals

KW - Schistosoma

KW - Mice

KW - Gene Expression Regulation

KW - Immunity

KW - Genes, Helminth

KW - Time Factors

KW - Antigens, Helminth

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Altered patterns of gene expression underlying the enhanced immunogenicity of radiation-attenuated schistosomes

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

Access to Document

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Cite this