Altered placental methyl donor transport in the dexamethasone programmed rat

C. S. Wyrwoll, D. Kerrigan, M. C. Holmes, J. R. Seckl, A. J. Drake

Research output: Contribution to journalArticlepeer-review

Abstract

There is increasing evidence for a role for epigenetic modifications in early life 'programming' effects. Altered placental methyl donor transport may impact on the establishment of epigenetic marks in the fetus. This study investigated the effects of prenatal glucocorticoid overexposure on placental methyl donor transport. Glucocorticoids increased folate but decreased choline transport and reduced fetal plasma methionine levels. There was no change in global DNA methylation in fetal liver. These data suggest prenatal glucocorticoid overexposure causes complex alterations in the placental transport of key methyl donors which may have important implications for maternal diet and nutrient supplementation in pregnancy.

Original languageEnglish
Pages (from-to)220-223
Number of pages4
JournalPlacenta
Volume33
Issue number3
DOIs
Publication statusPublished - Mar 2012

Keywords

  • early life programming
  • Epigenetics
  • methyl donors
  • DNA METHYLATION

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