Altered protein dynamics of disease-associated lamin A mutants

Susan Gilchrist, Nick Gilbert, Paul Perry, Cecilia Ostlund, Howard J Worman, Wendy A Bickmore

Research output: Contribution to journalArticlepeer-review

Abstract

Recent interest in the function of the nuclear lamina has been provoked by the discovery of lamin A/C mutations in the laminopathy diseases. However, it is not understood why mutations in lamin A give such a range of tissue-specific phenotypes. Part of the problem in rationalising genotype-phenotype correlations in the laminopathies is our lack of understanding of the function of normal and mutant lamin A. To investigate this we have used photobleaching in human cells to analyse the dynamics of wild-type and mutant lamin A protein at the nuclear periphery.
Original languageEnglish
Pages (from-to)46
JournalBMC Cell Biology
Volume5
Issue number1
DOIs
Publication statusPublished - 2004

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