Alternate transcription of the Toll-like receptor signaling cascade

Christine A Wells, Alistair M Chalk, Alistair Forrest, Darrin Taylor, Nic Waddell, Kate Schroder, S Roy Himes, Geoffrey Faulkner, Sandra Lo, Takeya Kasukawa, Hideya Kawaji, Chikatoshi Kai, Jun Kawai, Shintaro Katayama, Piero Carninci, Yoshihide Hayashizaki, David A Hume, Sean M Grimmond

Research output: Contribution to journalArticlepeer-review


Alternate splicing of key signaling molecules in the Toll-like receptor (Tlr) cascade has been shown to dramatically alter the signaling capacity of inflammatory cells, but it is not known how common this mechanism is. We provide transcriptional evidence of widespread alternate splicing in the Toll-like receptor signaling pathway, derived from a systematic analysis of the FANTOM3 mouse data set. Functional annotation of variant proteins was assessed in light of inflammatory signaling in mouse primary macrophages, and the expression of each variant transcript was assessed by splicing arrays.
Original languageEnglish
Pages (from-to)R10
JournalGenome Biology
Issue number2
Publication statusPublished - 2006


  • Alternative Splicing
  • Animals
  • DNA Primers
  • Gene Expression Profiling
  • Genetic Variation
  • Genome
  • Mammals
  • Oligonucleotide Array Sequence Analysis
  • Polymerase Chain Reaction
  • Signal Transduction
  • Toll-Like Receptor 4
  • Toll-Like Receptors
  • Transcription, Genetic


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