Alternatives to antibiotics in a One Health context and the role genomics can play in reducing antimicrobial use

Jolinda Pollock; Alison Low; Rebecca McHugh; Adrian Muwonge; Mark P Stevens; Alexander Corbishley; David L Gally

doi:10.1016/j.cmi.2020.02.028

Alternatives to antibiotics in a One Health context and the role genomics can play in reducing antimicrobial use

Jolinda Pollock, Alison Low, Rebecca McHugh, Adrian Muwonge, Mark P Stevens, Alexander Corbishley, David L Gally

Research output: Contribution to journal › Review article › peer-review

Abstract / Description of output

BACKGROUND: This review follows on from the International Conference on One Health Antimicrobial Resistance (ICOHAR 2019), where strategies to improve the fundamental understanding and management of antimicrobial resistance at the interface between humans, animals and the environment were discussed.

OBJECTIVE: This review identifies alternatives to antimicrobials in a One Health context, noting how advances in genomic technologies are assisting their development and enabling more targeted use of antimicrobials.

SOURCES: Key articles on the use of microbiota modulation, livestock breeding and gene editing, vaccination, anti-virulence strategies and bacteriophage therapy are discussed.

CONTENT: Antimicrobials are central for disease control, but reducing their use is paramount due to the rise of transmissible antimicrobial resistance. This review discusses antimicrobial alternatives in the context of improved understanding of fundamental host-pathogen and microbiota interactions using genomic tools.

IMPLICATIONS: Host and microbial genomics and other novel technologies have an important role to play in devising disease control strategies for healthier animals and humans that in turn reduce our reliance on antimicrobials.

Original language	English
Journal	Clinical Microbiology and Infection
Early online date	24 Mar 2020
DOIs	https://doi.org/10.1016/j.cmi.2020.02.028
Publication status	E-pub ahead of print - 24 Mar 2020

Access to Document

10.1016/j.cmi.2020.02.028

Revision-CLM-19-16576Accepted author manuscript, 109 KB

ISP 2 2017/22 Control of Infectious Diseases
Gally, D.
BBSRC
1/04/17 → 31/03/22
Project: Research

Cite this

@article{f6959faf1d99429eb65c3190100eb988,

title = "Alternatives to antibiotics in a One Health context and the role genomics can play in reducing antimicrobial use",

abstract = "BACKGROUND: This review follows on from the International Conference on One Health Antimicrobial Resistance (ICOHAR 2019), where strategies to improve the fundamental understanding and management of antimicrobial resistance at the interface between humans, animals and the environment were discussed.OBJECTIVE: This review identifies alternatives to antimicrobials in a One Health context, noting how advances in genomic technologies are assisting their development and enabling more targeted use of antimicrobials.SOURCES: Key articles on the use of microbiota modulation, livestock breeding and gene editing, vaccination, anti-virulence strategies and bacteriophage therapy are discussed.CONTENT: Antimicrobials are central for disease control, but reducing their use is paramount due to the rise of transmissible antimicrobial resistance. This review discusses antimicrobial alternatives in the context of improved understanding of fundamental host-pathogen and microbiota interactions using genomic tools.IMPLICATIONS: Host and microbial genomics and other novel technologies have an important role to play in devising disease control strategies for healthier animals and humans that in turn reduce our reliance on antimicrobials.",

author = "Jolinda Pollock and Alison Low and Rebecca McHugh and Adrian Muwonge and Stevens, {Mark P} and Alexander Corbishley and Gally, {David L}",

note = "Copyright {\textcopyright} 2020. Published by Elsevier Ltd.",

year = "2020",

month = mar,

day = "24",

doi = "10.1016/j.cmi.2020.02.028",

language = "English",

journal = "Clinical Microbiology and Infection",

issn = "1198-743X",

publisher = "Elsevier",

}

TY - JOUR

T1 - Alternatives to antibiotics in a One Health context and the role genomics can play in reducing antimicrobial use

AU - Pollock, Jolinda

AU - Low, Alison

AU - McHugh, Rebecca

AU - Muwonge, Adrian

AU - Stevens, Mark P

AU - Corbishley, Alexander

AU - Gally, David L

PY - 2020/3/24

Y1 - 2020/3/24

N2 - BACKGROUND: This review follows on from the International Conference on One Health Antimicrobial Resistance (ICOHAR 2019), where strategies to improve the fundamental understanding and management of antimicrobial resistance at the interface between humans, animals and the environment were discussed.OBJECTIVE: This review identifies alternatives to antimicrobials in a One Health context, noting how advances in genomic technologies are assisting their development and enabling more targeted use of antimicrobials.SOURCES: Key articles on the use of microbiota modulation, livestock breeding and gene editing, vaccination, anti-virulence strategies and bacteriophage therapy are discussed.CONTENT: Antimicrobials are central for disease control, but reducing their use is paramount due to the rise of transmissible antimicrobial resistance. This review discusses antimicrobial alternatives in the context of improved understanding of fundamental host-pathogen and microbiota interactions using genomic tools.IMPLICATIONS: Host and microbial genomics and other novel technologies have an important role to play in devising disease control strategies for healthier animals and humans that in turn reduce our reliance on antimicrobials.

AB - BACKGROUND: This review follows on from the International Conference on One Health Antimicrobial Resistance (ICOHAR 2019), where strategies to improve the fundamental understanding and management of antimicrobial resistance at the interface between humans, animals and the environment were discussed.OBJECTIVE: This review identifies alternatives to antimicrobials in a One Health context, noting how advances in genomic technologies are assisting their development and enabling more targeted use of antimicrobials.SOURCES: Key articles on the use of microbiota modulation, livestock breeding and gene editing, vaccination, anti-virulence strategies and bacteriophage therapy are discussed.CONTENT: Antimicrobials are central for disease control, but reducing their use is paramount due to the rise of transmissible antimicrobial resistance. This review discusses antimicrobial alternatives in the context of improved understanding of fundamental host-pathogen and microbiota interactions using genomic tools.IMPLICATIONS: Host and microbial genomics and other novel technologies have an important role to play in devising disease control strategies for healthier animals and humans that in turn reduce our reliance on antimicrobials.

U2 - 10.1016/j.cmi.2020.02.028

DO - 10.1016/j.cmi.2020.02.028

M3 - Review article

C2 - 32220638

SN - 1198-743X

JO - Clinical Microbiology and Infection

JF - Clinical Microbiology and Infection

ER -

Alternatives to antibiotics in a One Health context and the role genomics can play in reducing antimicrobial use

Abstract / Description of output

Access to Document

Fingerprint

Projects

ISP 2 2017/22 Control of Infectious Diseases

Cite this